ATRIAL FIBRILLATION (AF)

This completed study tested a new catheter and generator system designed to treat paroxysmal atrial fibrillation (AFib) — a common heart rhythm problem. The device uses pulsed field ablation (PFA) to target and destroy tiny areas of heart tissue causing the irregular rhythm. 188 …

This study tested whether using a 3D electroanatomic mapping system (FARAVIEW) during pulsed field ablation helps create more precise lesions in the pulmonary veins of people with atrial fibrillation. Thirty-two participants were randomly assigned to receive ablation with or with…

This study tested a systematic 12-step workflow for a newer type of heart ablation (pulsed-field ablation) in 118 adults with atrial fibrillation. The goal was to see if this approach could better isolate the pulmonary veins and reduce the chance of the heart rhythm problem retur…

This study tested whether using a 3D-printed model of a heart chamber helps doctors better plan a procedure to close off a small pouch in the heart. This pouch, called the left atrial appendage, is a common source of blood clots that can cause stroke in people with atrial fibrill…

This study tested whether a generic version of dronedarone hydrochloride tablets works the same as the brand-name drug MULTAQ in healthy adults. Fifty-one healthy male volunteers took a single dose of either the generic or brand drug under fasting conditions. The results showed t…

This study looked at whether rebamipide, a stomach-protecting drug, can prevent bleeding and ulcers in people with atrial fibrillation who take blood thinners (DOACs). 210 adults were randomly assigned to receive rebamipide, pantoprazole, or both for 24 weeks. The goal was to see…

This study tested a voltage-guided stepwise ablation strategy against the standard circumferential approach for treating atrial fibrillation. 130 adults with AF undergoing their first catheter ablation were randomly assigned to one of the two methods. The goal was to see if the s…

This study tested a single hybrid procedure that combines keyhole surgery with a catheter-based approach to treat complex atrial fibrillation (AF) in 12 patients. The goal was to see if this combined method could completely isolate the abnormal electrical signals in the heart. Th…

This study tested whether an artificial intelligence algorithm (ZywieAI) can accurately analyze heart rhythm data collected from a wearable sensor (ZywieZ3) worn for 24 hours. The sensor was placed in non-traditional positions on the chest. Researchers compared the AI's findings …

This study tested an online psychological program designed to prevent depression in people with atrial fibrillation (AF), a common heart rhythm problem. The program combined phone or video sessions with online modules and exercises over 4-12 weeks. The trial included 28 adults wi…

This study tested three different drug combinations to keep patients comfortable and still during a heart procedure called pulsed field ablation for atrial fibrillation. 240 adults were randomly assigned to one of three sedation groups. The goal was to see which method achieved t…

This study looked at 172 people with atrial fibrillation who had a heart procedure guided by a special ultrasound. Researchers found a common harmless imaging artifact, called the 'Floating Lotus' sign, that can look like a dangerous blood clot. By learning to tell the difference…

This study tested a special breathing technique during atrial fibrillation ablation to see if it reduces catheter movement. Fifty-two adults with atrial fibrillation were given both standard and high-frequency, low-volume ventilation during their procedure. The goal was to see if…

This study tested whether an augmented reality (AR) tool, accessed via a QR code on a smartphone, could help heart patients better understand their discharge instructions. 303 adults hospitalized for heart attack, heart failure, atrial fibrillation, or pacemaker implantation took…

This study tested whether a generic version of dronedarone hydrochloride (400 mg tablets) works the same as the brand-name drug MULTAQ in 48 healthy Chinese adults. Participants took a single dose under fed conditions, and researchers measured drug levels in the blood to check fo…

This study compared two methods for a key step in atrial fibrillation ablation—puncturing the wall between heart chambers—without using any X-rays. Both techniques used ultrasound instead. The trial involved 28 patients and measured how long each method took, whether X-rays were …

This pilot study involved 9 people with atrial fibrillation undergoing a first-time pulsed field ablation procedure. Researchers collected heart signal data to test a new algorithm that automatically measures local electrical activity. The goal was to see if the automated measure…

This study looked at 40 adults with atrial fibrillation (an irregular heartbeat) to compare two ways of performing a common treatment called pulmonary vein isolation. One method uses advanced 3D heart mapping, while the other relies on standard X-ray guidance. The goal was to see…