One drug at a time: could a simpler blood thinner strategy cut bleeding risk after stents?
NCT ID NCT05955365
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new approach for people with atrial fibrillation who have just received a coronary stent. Instead of taking multiple blood thinners together for months, the experimental group takes only one antiplatelet drug for the first month, then switches to a single anticoagulant. The goal is to see if this simpler routine reduces bleeding complications while still preventing heart attacks, strokes, and stent blockages. About 3,000 participants will be compared to those receiving the standard combination therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
P2Y12 inhibitor (antiplatelet drug) followed by a direct-acting oral anticoagulant (DOAC)
What this could lead to
If this works, it could offer a simpler, safer blood-thinning routine for people with atrial fibrillation who have just had a coronary stent, lowering their risk of serious bleeding without raising the chance of heart attack or stroke.
What could go wrong
This is a large Phase 4 trial, but the strategy is still experimental. It may not protect against stent clotting or stroke as well as the current triple-drug approach, and individual responses to the drugs can vary.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU Nîmes
NOT_YET_RECRUITINGNîmes, 30029, France
Contact Email: •••••@•••••
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Cardiocentro Ticino Institute
RECRUITINGLugano, Canton Ticino, 6900, Switzerland
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hartcentrum Hasselt
NOT_YET_RECRUITINGHasselt, 3500, Belgium
Contact Email: •••••@•••••
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Hospital Universitario Marques de Valdecilla
NOT_YET_RECRUITINGSantander, 39008, Spain
Contact Email: •••••@•••••
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Hôpitaux Universitaires de Genève
RECRUITINGGeneva, 1211, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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IRCCS Humanitas
NOT_YET_RECRUITINGMilan, Rozzano, 20089, Italy
Contact Email: •••••@•••••
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Imperial College London
NOT_YET_RECRUITINGLondon, SW7 2AZ, United Kingdom
Contact Email: •••••@•••••
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Inselspital, Bern University Hospital, Department of Cardiology
RECRUITINGBern, 3010, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum Friedrichshafen
NOT_YET_RECRUITINGFriedrichshafen, 88048, Germany
Contact Email: •••••@•••••
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Ospedale Ferrarotto
NOT_YET_RECRUITINGCatania, Catania CT, 95124, Italy
Contact Email: •••••@•••••
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UMC public
NOT_YET_RECRUITINGAmsterdam, 1081, Netherlands
Contact Email: •••••@•••••
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University Hospital Zürich
RECRUITINGZurich, 8091, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Frankfurt/Main
NOT_YET_RECRUITINGFrankfurt am Main, 60590, Germany
Contact Email: •••••@•••••
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Universitätsspital Basel
RECRUITINGBasel, 4031, Switzerland
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
NOT_YET_RECRUITINGPoznan, 61-701, Poland
Contact Email: •••••@•••••