MAJOR DEPRESSION

This study is testing whether a stronger dose of a safe, non-invasive brain stimulation technique can be used to treat depression. Participants with major depression will receive mild electrical stimulation through a headset for 5 days while researchers closely monitor for side e…

This study is testing a new diagnostic tool that combines a blood test with a short questionnaire to help doctors tell the difference between bipolar disorder and regular depression. It involves about 623 adults who are currently experiencing a depressive episode and are visiting…

This study aims to identify biological markers that predict how well different brain stimulation and medication treatments work for severe depression and obsessive-compulsive disorder (OCD). Researchers will collect data from 1,000 patients receiving treatments like electroconvul…

This study aims to understand how morning grogginess (sleep inertia) affects people with depression. Researchers will compare attention and alertness tests in three groups: depressed people with morning grogginess, depressed people without it, and healthy controls. The study uses…

This study aims to understand how ketamine, a drug known to relieve depression symptoms within hours, works in the brain. Researchers will test whether blocking a specific brain receptor (called AMPA) reduces ketamine's antidepressant effects. About 70 adults with major depressio…

This study aims to understand how breathing exercises and aerobic workouts affect certain chemicals in the body and brain of people with major depression. Researchers will measure markers related to brain cell health, inflammation, and stress in 40 adult volunteers. The goal is t…

This study aims to understand the connection between physical activity, sleep, and mental health in people with and without mood disorders like bipolar disorder and depression. Over 1,200 participants, including patients and their healthy family members, will wear activity monito…

This study aims to understand why older adults with depression often experience memory and thinking problems. Researchers will follow 120 participants with depression over 30 months, using brain scans, blood tests, and memory assessments. The goal is to learn how depression might…

This is a long-term research project gathering health information from 10,000 people in the U.S. to build a detailed picture of brain inflammation and related conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants, including both affected and healthy individual…

This study aims to find genetic markers that can predict which children and young adults might experience a troubling side effect called 'behavioral activation' from common antidepressant medications (SSRIs). Researchers will compare the DNA of 160 young people (ages 6-24) who ei…