MAJOR DEPRESSION
Clinical trials for MAJOR DEPRESSION explained in plain language.
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New pulse therapy for depression put to the test
Symptom relief CompletedThis study tested a new treatment called transcranial pulse stimulation (TPS) for people with major depression. 80 adults received either real TPS or a fake (sham) version to see if it safely reduces depressive symptoms. The goal is to find out if this non-invasive brain therapy …
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: The Hong Kong Polytechnic University • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Brain zaps battle blues: which TMS works best?
Symptom relief CompletedThis study tested two forms of transcranial magnetic stimulation (TMS) in 108 adults with major depression. Participants received either high-frequency or theta-burst TMS over two weeks. Researchers measured depression and anxiety before, after, and six weeks later to see which m…
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: Krajská zdravotní, a.s. - Nemocnice Most, o.z. • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Brain scans reveal link between depression and Alzheimer's plaques in seniors
Knowledge-focused CompletedThis study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to unde…
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: University Hospital, Tours • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Brain zap tunes heart and gut: new hope for depression?
Knowledge-focused CompletedThis completed study tested whether noninvasive brain stimulation can be personalized by measuring heart rate responses. Researchers mapped the scalp to find the best spot for stimulation in 34 healthy participants and people with depression, anxiety, and gut issues. They compare…
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: University of Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Can an automated phone call help monitor mental health?
Knowledge-focused CompletedThis pilot study tested an automated phone system called 'My Coach Connect' for people with chronic mental illness. Participants called in twice a week to answer questions about how they were doing. The goal was to see if the system was easy to use and helpful for both patients a…
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: RAND • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Brain wave test may reveal if your antidepressant is working
Knowledge-focused CompletedThis study tested whether brain wave patterns (measured by QEEG) can predict how well people with major depression respond to the antidepressant venlafaxine (Effexor). Thirty-eight adults with depression received either venlafaxine or a placebo for a short time, then continued wi…
Matched conditions: MAJOR DEPRESSION
Phase: PHASE4 • Sponsor: University of California, Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC