MAJOR DEPRESSION
Clinical trials for MAJOR DEPRESSION explained in plain language.
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Brain pulse therapy shows promise for depression in new trial
Symptom relief CompletedThis study tested a new, non-invasive brain stimulation called transcranial pulse stimulation (TPS) for people with major depression. 80 adults received either real TPS or a sham treatment over six weeks. The goal was to see if TPS can safely reduce depressive symptoms, offering …
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: The Hong Kong Polytechnic University • Aim: Symptom relief
Last updated May 15, 2026 12:00 UTC
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Brain zaps battle blues: which TMS works best?
Symptom relief CompletedThis study tested two forms of transcranial magnetic stimulation (TMS) — high-frequency and theta-burst — in 108 adults with major depression. Participants received 10 sessions over two weeks, and researchers tracked their depression and anxiety symptoms for six weeks afterward. …
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: Krajská zdravotní, a.s. - Nemocnice Most, o.z. • Aim: Symptom relief
Last updated May 12, 2026 13:40 UTC
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Brain scan may predict depression treatment response
Knowledge-focused CompletedThis study looked at whether brain wave patterns (EEG) can show early on if an antidepressant is working. Thirty-eight adults with major depression took part. The goal was to see if changes in brain activity happen before mood improves, which could help doctors choose the right t…
Matched conditions: MAJOR DEPRESSION
Phase: PHASE4 • Sponsor: University of California, Los Angeles • Aim: Knowledge-focused
Last updated May 17, 2026 00:43 UTC
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Can a simple phone call improve mental health care? new study says maybe.
Knowledge-focused CompletedThis pilot study tested a new automated phone system called 'My Coach Connect' for people with chronic mental illness. Participants called the system twice a week to share how they were doing, and their providers could listen to the recordings. The goal was to see if this tool co…
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: RAND • Aim: Knowledge-focused
Last updated May 17, 2026 00:42 UTC
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Brain zaps tuned to your heartbeat: a new way to treat depression?
Knowledge-focused CompletedThis study tested a new way to personalize brain stimulation for depression by using heart rate responses to guide treatment. Researchers mapped the brain to find the best spot for stimulation in 34 healthy volunteers and people with depression. The goal was to better understand …
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: University of Bern • Aim: Knowledge-focused
Last updated May 17, 2026 00:29 UTC
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Zapping the brain during sleep: a new hope for depression?
Knowledge-focused CompletedThis small study from Stanford tested whether giving a gentle magnetic pulse to the brain during deep sleep could help treat depression. Fifteen adults with major depression who hadn't gotten better with medication took part. The goal was to see if this approach is safe and might…
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated May 14, 2026 12:06 UTC