MAJOR DEPRESSION

This study tests a new group program called Forging New Paths for adults with serious mental illness who have also been involved with the criminal justice system. The program combines cognitive behavioral therapy with social learning techniques to reduce aggression and help peopl…

This trial tests whether choline alphoscerate, a dietary supplement, can improve depression, anxiety, and memory complaints in adults aged 60 and older with major depression. Participants take either the supplement or a placebo alongside their usual antidepressant medication. The…

This study tested a new treatment called transcranial pulse stimulation (TPS) for people with major depression. 80 adults received either real TPS or a fake (sham) version to see if it safely reduces depressive symptoms. The goal is to find out if this non-invasive brain therapy …

This study tested two forms of transcranial magnetic stimulation (TMS) in 108 adults with major depression. Participants received either high-frequency or theta-burst TMS over two weeks. Researchers measured depression and anxiety before, after, and six weeks later to see which m…

This study tests whether breathing exercises and aerobic exercise can change levels of certain brain and inflammation markers in people with major depression. Forty adults diagnosed with depression will do daily breathing and aerobic exercises for three weeks. Researchers will me…

This study uses brain scans to explore how sleep and mood are connected in people with major depression compared to healthy volunteers. Participants undergo overnight sleep deprivation while researchers measure changes in brain activity, fluid flow, and mood. The goal is to uncov…

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to unde…

This completed study tested whether noninvasive brain stimulation can be personalized by measuring heart rate responses. Researchers mapped the scalp to find the best spot for stimulation in 34 healthy participants and people with depression, anxiety, and gut issues. They compare…

This pilot study tested an automated phone system called 'My Coach Connect' for people with chronic mental illness. Participants called in twice a week to answer questions about how they were doing. The goal was to see if the system was easy to use and helpful for both patients a…

This study tested whether brain wave patterns (measured by QEEG) can predict how well people with major depression respond to the antidepressant venlafaxine (Effexor). Thirty-eight adults with depression received either venlafaxine or a placebo for a short time, then continued wi…