Brain scans reveal link between depression and Alzheimer's plaques in seniors

NCT ID NCT01962753

Completed Knowledge-focused Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to understand how depression and these brain changes are connected, not to test a new treatment.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ELDERLY MAJOR DEPRESSION

Contacts and locations

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Locations

Le Rouvray Hospital

Sotteville-lès-Rouen, 76300, France
Sainte-Anne Hospital

Paris, 75014, France
University Hospital of Besançon- Jean Minjoz

Besançon, 25030, France
University Hospital of Caen

Caen, 14000, France
University Hospital of Lille

Lille, 59000, France
University Hospital of Nice

Nice, 06000, France
University Hospital of Strasbourg - HUS

Strasbourg, 67098, France
University Hospital of Toulouse - Purpan

Toulouse, 31059, France
University Hospital of Tours

Tours, 37000, France
University hospital of Rennes-Guillaume Régnier

Rennes, 35000, France

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