Could a Custom-Tailored therapy beat standard talk therapy for tough depression?

NCT ID NCT07380451

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new type of talk therapy that is personalized for each person's emotional, relationship, and self-image struggles. It is for adults with depression that also involves personality problems or past trauma. 150 people in Chile's public health system will get either this modular therapy or usual one-on-one therapy. The goal is to see if the personalized approach leads to more people feeling better and staying well.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Modular Intervention for Depression Therapy (MIND Therapy) - a personalized psychotherapy

What this could lead to

If successful, this could provide a more effective, personalized therapy option for depression complicated by personality issues or trauma, especially in public health settings.

What could go wrong

This is a small pilot study (150 people) in one country's public system, so results may not apply broadly. The therapy is complex and may not outperform usual care.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CDT CASR

    RECRUITING

    Santiago, Chile

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • COSAM La Bandera

    ACTIVE_NOT_RECRUITING

    Santiago, Chile

  • COSAM La Granja

    RECRUITING

    Santiago, Chile

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • COSAM La Pintana

    RECRUITING

    Santiago, Chile

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • COSAM Rinconada

    RECRUITING

    Santiago, Chile

    Contact Phone: •••-•••-•••• Email: •••••@•••••