New hope for schizophrenia: KarXT enters Late-Stage trial

NCT ID NCT06882785

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 28, 2026 · Updated 5 times

Summary

This phase 3 study tests whether KarXT, a new drug, can safely reduce schizophrenia symptoms in 250 Japanese adults experiencing acute psychosis. Participants first receive either KarXT or a placebo for 5 weeks, then all may receive KarXT for a year. The goal is to see if KarXT improves symptoms like hallucinations and disorganized thinking.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: KarXT (also known as BMS-986510)
What this could lead to: If successful, KarXT could offer a new treatment option for schizophrenia, helping to control symptoms like hallucinations and delusions.
What could go wrong: This is a phase 3 trial, but it is still early to know if KarXT works better than existing treatments. Side effects are possible, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

Asuka Hospital
RECRUITING

Machida, Tokyo, 1940005, Japan
Dokkyo Medical University Hospital
RECRUITING

Shimotsuga, Tochigi, 321-0293, Japan
Fujimidai Hospital
RECRUITING

Hiratsuka, Kanagawa, 259-1205, Japan
Fujita Health University
RECRUITING

Toyoake, Aichi-ken, 470-1192, Japan
Goryokai Medical Corporation - Goryokai Hospital
RECRUITING

Sapporo, Hokkaido, 002-8029, Japan
Hino Hospital - Yokohama
RECRUITING

Yokohama, Kanagawa, 234-0051, Japan
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 0608648, Japan
Holy Cross Hospital - Toki
RECRUITING

Toki, Gifu, 509-5142, Japan
Hotei Hospital
RECRUITING

Kōnan, Aichi-ken, 4838248, Japan
Inuo Hospital
RECRUITING

Tosu, Saga-ken, 841-0081, Japan
Kansai Medical University Medical Center
RECRUITING

Moriguchi, Osaka, 570-8507, Japan
Kitasato University Hospital
RECRUITING

Sagamihara, Kanagawa, 252-0375, Japan
Kuramitsu Hospital
RECRUITING

Fukuoka, 819-0037, Japan
Kure Medical Center
RECRUITING

Kure, Hiroshima, 737-0023, Japan
Local Institution - 0012
WITHDRAWN

Hachiōji, Tokyo, 192-0153, Japan
Local Institution - 0014
WITHDRAWN

Komoro, Nagano, 384-8540, Japan
Local Institution - 0018
NOT_YET_RECRUITING

Okinawa, 904-0012, Japan
Local Institution - 0019
WITHDRAWN

Yatsushiro, Kumamoto, 866-0043, Japan
Local Institution - 0025
NOT_YET_RECRUITING

Hadano-shi, Kanagawa, 257-0003, Japan
Local Institution - 0031
NOT_YET_RECRUITING

Osaka, 590-0018, Japan
Local Institution - 0032
WITHDRAWN

Iizuka, Fukuoka, 820-0014, Japan
Local Institution - 0033
WITHDRAWN

Tottori, 689-0203, Japan
Local Institution - 0037
NOT_YET_RECRUITING

Kitakyushu, Fukuoka, 803-0831, Japan
Local Institution - 0050
WITHDRAWN

Matsumoto, Nagano, 390-0847, Japan
Local Institution - 0054
NOT_YET_RECRUITING

Shimotsuke, Tochigi, 329-0498, Japan
Local Institution - 0056
NOT_YET_RECRUITING

Nagoya, Aichi-ken, 466-8560, Japan
Miyakonojo Shinsei Hospital
RECRUITING

Miyakonojō, Miyazaki, 885-0093, Japan
Miyazaki Prefectural Miyazaki Hospital
RECRUITING

Miyazaki, 880-8510, Japan
Nagaokai Medical Corporation - Neyagawa Sanatorium
RECRUITING

Neyagawa, Osaka, 572-0854, Japan
Narimasu Kosei Hospital
RECRUITING

tabashi City, Tokyo, 175-0091, Japan
National Center of Neurology and Psychiatry
RECRUITING

Kodaira, Tokyo, 187-8551, Japan
National Hospital Organization Maizuru Medical Center
RECRUITING

Maizuru, Kyoto, 625-8502, Japan
National Hospital Organization Shimofusa Psychiatric Medical Center
RECRUITING

MIdori-ku, Chiba-shi, Chiba, 266-0007, Japan
National Kohnodai Medical Center.
RECRUITING

Ichikawa, Chiba, 272-8516, Japan
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Okehazama Hospital
RECRUITING

Toyoake, Aichi-ken, 470-1168, Japan
Osaka Medical and Pharmaceutical University Hospital
RECRUITING

Takatsuki, Osaka, 569-8686, Japan
Osaka Psychiatric Medical Center
RECRUITING

Hirakata, Osaka, 573-0022, Japan
Rainbow and Sea Hospital
RECRUITING

Karatsu-shi, Saga-ken, 847-0031, Japan
Saitama Konan Hospital
RECRUITING

Kumagaya, Saitama, 360-0114, Japan
Saitama Neuropsychitric Institute
RECRUITING

Saitama, 338-8577, Japan
Shin-Abuyama Hospital
RECRUITING

Takatsuki, Osaka, 569-1041, Japan
Shiranui Hospital
RECRUITING

Omuta, Fukuoka, 836-0004, Japan
Takeda General Hospital - Aizuwakamatsu
RECRUITING

Aizu-Wakamatsu, Fukushima, 965-0876, Japan
Tochigi Prefectural Okamotodai Hospital
RECRUITING

Utsunomiya, Tochigi, 3291104, Japan
Toho University Omori Medical Center
RECRUITING

Ōta-ku, Tokyo, 143-8541, Japan
Tokushima University Hospital
RECRUITING

Tokushima, 770-8503, Japan
Tokyo Metropolitan Matsuzawa Hospital
RECRUITING

Setagaya City, Tokyo, 1560057, Japan
Tsurumi Nishii Hospital
RECRUITING

Yokohama, Kanagawa, 230-0074, Japan
University Hospital,Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, 602-8566, Japan
University of the Ryukyus Hospital
RECRUITING

Ginowan, Okinawa, 901-2725, Japan
Wakayama Medical University Hospital
RECRUITING

Wakayama, 641-8510, Japan
Yamagata Sakuracho Hospital
RECRUITING

Yamagata, 990-0045, Japan
Yamaguchi University Hospital
RECRUITING

Ube, Yamaguchi, 755-8505, Japan
Yokohama City University Medical Center
RECRUITING

Yokohama, Kanagawa, 232-0024, Japan
Yuge Hospital
RECRUITING

Kumamoto, Kumamoto, 861-8002, Japan

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