New schizophrenia drug KarXT under scrutiny for bladder safety

NCT ID NCT07221877

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing how the drug KarXT affects bladder function and overall safety in 60 adults with schizophrenia over 12 months. Participants will stop their current antipsychotics and take KarXT to see if it causes any urinary problems. The goal is to ensure the drug is safe for long-term use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: KarXT (xanomeline and trospium chloride)
What this could lead to: If successful, this study could show that KarXT is safe for the bladder and urinary system, supporting its use as a long-term treatment for schizophrenia.
What could go wrong: This is a small, open-label safety study with no placebo group, so results may not prove effectiveness. Side effects related to bladder function or other issues could still arise.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

ATP Clinical Research
RECRUITING

Orange, California, 92866, United States
Adams Clinical Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
CenExel CNS - Garden Grove
RECRUITING

Garden Grove, California, 92845, United States
Clinical Innovations, Inc. dba CITrials
RECRUITING

Bellflower, California, 90706, United States
Hassman Research Institute Marlton Site
RECRUITING

Marlton, New Jersey, 08053, United States
Health Synergy Clinical Research
RECRUITING

West Palm Beach, Florida, 33407, United States
IMA Clinical Research Las Vegas
RECRUITING

Las Vegas, Nevada, 89102, United States
InSite Clinical Research
RECRUITING

DeSoto, Texas, 75115, United States
Innovative Clinical Research
RECRUITING

Lauderhill, Florida, 33319, United States
Local Institution - 0001
NOT_YET_RECRUITING

Austin, Texas, 78754, United States
Pillar Clinical Research -Chicago
RECRUITING

Chicago, Illinois, 60641, United States
Pillar Clinical Research- Little Rock
RECRUITING

Little Rock, Arkansas, 72204, United States
Uptown Research Institute
RECRUITING

Chicago, Illinois, 60640, United States

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