New schizophrenia drug KarXT under Real-World scrutiny
NCT ID NCT07379827
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tracks 1,500 adults with schizophrenia who start taking KarXT (xanomeline and trospium chloride) in routine clinical care across the U.S. Researchers will monitor how doctors adjust doses, side effects, weight changes, and relapses over time. The goal is to understand how well the drug works outside of controlled trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Xanomeline and trospium chloride (KarXT)
What this could lead to
If successful, this study could provide real-world evidence on how well KarXT works for schizophrenia and its side effects, helping doctors make better treatment decisions.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by factors like patient selection or incomplete data. It does not test a new drug but rather monitors existing use.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Banyan Behavioal Care Program - CSU
RECRUITINGMiami, Florida, 33134, United States
Contact Phone: •••-•••-••••
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BioResearch Partner - Miami
RECRUITINGMiami, Florida, 33175, United States
Contact
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Envision Trials LLC
RECRUITINGBonita Springs, Florida, 34134, United States
Contact Phone: •••-•••-••••
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Galiz Research
RECRUITINGHialeah, Florida, 33016-1814, United States
Contact Phone: •••-•••-••••
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Local Institution - 0003
NOT_YET_RECRUITINGAnaheim, California, 92805, United States
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Local Institution - 0004
NOT_YET_RECRUITINGMonsey, New York, 10952, United States
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Local Institution - 0007
NOT_YET_RECRUITINGMiami, Florida, 33155, United States
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Local Institution - 0010
NOT_YET_RECRUITINGHouston, Texas, 77054, United States
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Local Institution - 0012
NOT_YET_RECRUITINGLa Palma, California, 90623, United States
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Local Institution - 0013
NOT_YET_RECRUITINGMcKinney, Texas, 75092, United States
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Local Institution - 0014
NOT_YET_RECRUITINGBloomfield Township, Michigan, 48302-1909, United States
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Local Institution - 0016
NOT_YET_RECRUITINGAustin, Texas, 78754, United States
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Local Institution - 0017
NOT_YET_RECRUITINGIrving, Texas, 75062-2757, United States
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Local Institution - 0018
NOT_YET_RECRUITINGStafford, Texas, 77477-3954, United States
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Local Institution - 0020
NOT_YET_RECRUITINGWhite Plains, New York, 10601, United States
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Local Institution - 0021
NOT_YET_RECRUITINGFort Worth, Texas, 76132, United States
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Local Institution - 0022
NOT_YET_RECRUITINGHouston, Texas, 77054-2852, United States
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Local Institution - 0025
NOT_YET_RECRUITINGAtlanta, Georgia, 30303, United States
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Local Institution - 0026
NOT_YET_RECRUITINGHouston, Texas, 77008-1758, United States
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Local Institution - 0028
NOT_YET_RECRUITINGStanford, California, 94304, United States
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Local Institution - 0030
NOT_YET_RECRUITINGHomestead, Florida, 33030, United States
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Local Institution - 0031
NOT_YET_RECRUITINGMason, Ohio, 45040-7846, United States
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Local Institution - 0032
NOT_YET_RECRUITINGMiami, Florida, 33015, United States
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Local Institution - 0033
NOT_YET_RECRUITINGHouston, Texas, 77007-9015, United States
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Local Institution - 0034
NOT_YET_RECRUITINGApple Valley, Minnesota, 55124, United States
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Local Institution - 0035
NOT_YET_RECRUITINGSan Antonio, Texas, 78240, United States
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Local Institution - 0036
NOT_YET_RECRUITINGDetroit, Michigan, 48203, United States
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Local Institution - 0037
NOT_YET_RECRUITINGBuffalo, New York, 14215, United States
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Local Institution - 0038
NOT_YET_RECRUITINGRochester, New York, 14623, United States
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Local Institution - 0039
NOT_YET_RECRUITINGChino, California, 91710, United States
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Local Institution - 0040
NOT_YET_RECRUITINGOrlando, Florida, 32803, United States
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Local Institution - 0041
NOT_YET_RECRUITINGLincoln, Nebraska, 68526-9474, United States
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Local Institution - 0042
NOT_YET_RECRUITINGCary, North Carolina, 27513, United States
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Local Institution - 0043
NOT_YET_RECRUITINGOceanside, California, 92056-4509, United States
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Local Institution - 0044
NOT_YET_RECRUITINGMarietta, Georgia, 30060, United States
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Local Institution - 0045
NOT_YET_RECRUITINGPetersburg, Virginia, 23805, United States
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Local Institution - 0046
NOT_YET_RECRUITINGCrystal Lake, Illinois, 60523, United States
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Local Institution - 0047
NOT_YET_RECRUITINGAnaheim, California, 92801, United States
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Local Institution - 0048
NOT_YET_RECRUITINGWarrenville, Illinois, 60555, United States
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Local Institution - 0049
NOT_YET_RECRUITINGAustell, Georgia, 30106, United States
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Local Institution - 0050
NOT_YET_RECRUITINGDallas, Texas, 75390, United States
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Local Institution - 0051
NOT_YET_RECRUITINGCordova, Tennessee, 38018, United States
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Local Institution - 0052
NOT_YET_RECRUITINGTulsa, Oklahoma, 74135, United States
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Medical Research of Central Florida
RECRUITINGOrange City, Florida, 32763, United States
Contact Phone: •••-•••-••••
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New Access Research & Medical Services Inc - Kendall
RECRUITINGKendall, Florida, 33186, United States
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PPD Virtual - PPD - US
RECRUITINGWilmington, North Carolina, 28401-3331, United States
Contact Phone: •••-•••-••••
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Perceptive Pharma Research
RECRUITINGRichmond, Texas, 77407-3498, United States
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Perelman School of Medicine at the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104-4238, United States
Contact Phone: •••-•••-••••
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Pioneer Research Solutions, Inc.
RECRUITINGHouston, Texas, 77099, United States
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Psychiatric Consultants, Pc
RECRUITINGFranklin, Tennessee, 37607, United States
Contact Phone: •••-•••-••••
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SanRo Clinical Research Group
RECRUITINGBryant, Arkansas, 72022, United States
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The Rivus Wellness & Research Institute
RECRUITINGOklahoma City, Oklahoma, 73112-8729, United States
Contact Phone: •••-•••-••••