New schizophrenia drug KarXT under Real-World scrutiny

NCT ID NCT07379827

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tracks 1,500 adults with schizophrenia who start taking KarXT (xanomeline and trospium chloride) in routine clinical care across the U.S. Researchers will monitor how doctors adjust doses, side effects, weight changes, and relapses over time. The goal is to understand how well the drug works outside of controlled trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Xanomeline and trospium chloride (KarXT)
What this could lead to: If successful, this study could provide real-world evidence on how well KarXT works for schizophrenia and its side effects, helping doctors make better treatment decisions.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by factors like patient selection or incomplete data. It does not test a new drug but rather monitors existing use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

Banyan Behavioal Care Program - CSU
RECRUITING

Miami, Florida, 33134, United States
BioResearch Partner - Miami
RECRUITING

Miami, Florida, 33175, United States
Envision Trials LLC
RECRUITING

Bonita Springs, Florida, 34134, United States
Galiz Research
RECRUITING

Hialeah, Florida, 33016-1814, United States
Local Institution - 0003
NOT_YET_RECRUITING

Anaheim, California, 92805, United States
Local Institution - 0004
NOT_YET_RECRUITING

Monsey, New York, 10952, United States
Local Institution - 0007
NOT_YET_RECRUITING

Miami, Florida, 33155, United States
Local Institution - 0010
NOT_YET_RECRUITING

Houston, Texas, 77054, United States
Local Institution - 0012
NOT_YET_RECRUITING

La Palma, California, 90623, United States
Local Institution - 0013
NOT_YET_RECRUITING

McKinney, Texas, 75092, United States
Local Institution - 0014
NOT_YET_RECRUITING

Bloomfield Township, Michigan, 48302-1909, United States
Local Institution - 0016
NOT_YET_RECRUITING

Austin, Texas, 78754, United States
Local Institution - 0017
NOT_YET_RECRUITING

Irving, Texas, 75062-2757, United States
Local Institution - 0018
NOT_YET_RECRUITING

Stafford, Texas, 77477-3954, United States
Local Institution - 0020
NOT_YET_RECRUITING

White Plains, New York, 10601, United States
Local Institution - 0021
NOT_YET_RECRUITING

Fort Worth, Texas, 76132, United States
Local Institution - 0022
NOT_YET_RECRUITING

Houston, Texas, 77054-2852, United States
Local Institution - 0025
NOT_YET_RECRUITING

Atlanta, Georgia, 30303, United States
Local Institution - 0026
NOT_YET_RECRUITING

Houston, Texas, 77008-1758, United States
Local Institution - 0028
NOT_YET_RECRUITING

Stanford, California, 94304, United States
Local Institution - 0030
NOT_YET_RECRUITING

Homestead, Florida, 33030, United States
Local Institution - 0031
NOT_YET_RECRUITING

Mason, Ohio, 45040-7846, United States
Local Institution - 0032
NOT_YET_RECRUITING

Miami, Florida, 33015, United States
Local Institution - 0033
NOT_YET_RECRUITING

Houston, Texas, 77007-9015, United States
Local Institution - 0034
NOT_YET_RECRUITING

Apple Valley, Minnesota, 55124, United States
Local Institution - 0035
NOT_YET_RECRUITING

San Antonio, Texas, 78240, United States
Local Institution - 0036
NOT_YET_RECRUITING

Detroit, Michigan, 48203, United States
Local Institution - 0037
NOT_YET_RECRUITING

Buffalo, New York, 14215, United States
Local Institution - 0038
NOT_YET_RECRUITING

Rochester, New York, 14623, United States
Local Institution - 0039
NOT_YET_RECRUITING

Chino, California, 91710, United States
Local Institution - 0040
NOT_YET_RECRUITING

Orlando, Florida, 32803, United States
Local Institution - 0041
NOT_YET_RECRUITING

Lincoln, Nebraska, 68526-9474, United States
Local Institution - 0042
NOT_YET_RECRUITING

Cary, North Carolina, 27513, United States
Local Institution - 0043
NOT_YET_RECRUITING

Oceanside, California, 92056-4509, United States
Local Institution - 0044
NOT_YET_RECRUITING

Marietta, Georgia, 30060, United States
Local Institution - 0045
NOT_YET_RECRUITING

Petersburg, Virginia, 23805, United States
Local Institution - 0046
NOT_YET_RECRUITING

Crystal Lake, Illinois, 60523, United States
Local Institution - 0047
NOT_YET_RECRUITING

Anaheim, California, 92801, United States
Local Institution - 0048
NOT_YET_RECRUITING

Warrenville, Illinois, 60555, United States
Local Institution - 0049
NOT_YET_RECRUITING

Austell, Georgia, 30106, United States
Local Institution - 0050
NOT_YET_RECRUITING

Dallas, Texas, 75390, United States
Local Institution - 0051
NOT_YET_RECRUITING

Cordova, Tennessee, 38018, United States
Local Institution - 0052
NOT_YET_RECRUITING

Tulsa, Oklahoma, 74135, United States
Medical Research of Central Florida
RECRUITING

Orange City, Florida, 32763, United States
New Access Research & Medical Services Inc - Kendall
RECRUITING

Kendall, Florida, 33186, United States
PPD Virtual - PPD - US
RECRUITING

Wilmington, North Carolina, 28401-3331, United States
Perceptive Pharma Research
RECRUITING

Richmond, Texas, 77407-3498, United States
Perelman School of Medicine at the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104-4238, United States
Pioneer Research Solutions, Inc.
RECRUITING

Houston, Texas, 77099, United States
Psychiatric Consultants, Pc
RECRUITING

Franklin, Tennessee, 37607, United States
SanRo Clinical Research Group
RECRUITING

Bryant, Arkansas, 72022, United States
The Rivus Wellness & Research Institute
RECRUITING

Oklahoma City, Oklahoma, 73112-8729, United States

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