Brain patch trial aims to sharpen thinking in schizophrenia

NCT ID NCT06502964

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a skin patch called ALTO-101 can improve cognitive function in people with schizophrenia who have thinking problems. About 82 participants will receive either the active patch or a placebo, then switch after a period. The main goal is to see changes in brain wave activity linked to cognition, along with safety and tolerability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ALTO-101

What this could lead to

If successful, this could point toward a new treatment for cognitive problems in schizophrenia, potentially improving thinking and daily function.

What could go wrong

This is an early Phase 2 trial with only 82 people. It measures brain activity, not real-world thinking, so even positive results may not translate to meaningful benefits. Side effects are unknown.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Site 5015

    RECRUITING

    Tampa, Florida, 33629, United States

  • Site 5035

    RECRUITING

    Walnut Creek, California, 94596, United States

    Contact

  • Site 5038

    RECRUITING

    Garden Grove, California, 92845, United States

    Contact

  • Site 5056

    RECRUITING

    Chicago, Illinois, 60640, United States

    Contact

  • Site 5060

    RECRUITING

    Hollywood, Florida, 33024, United States

    Contact

  • Site 5062

    RECRUITING

    Gaithersburg, Maryland, 20877, United States

    Contact

  • Site 5063

    RECRUITING

    Los Angeles, California, 90015, United States

    Contact

  • Site 5064

    RECRUITING

    Snellville, Georgia, 30078, United States

    Contact

  • Site 5077

    RECRUITING

    New York, New York, 10032, United States

    Contact

  • Site 5106

    RECRUITING

    Orange, California, 92868, United States

    Contact

  • Site 5108

    RECRUITING

    New York, New York, 10027, United States

    Contact

  • Site 5109

    WITHDRAWN

    New York, New York, 10035, United States

  • Site 5124

    RECRUITING

    Belmont, Massachusetts, 02478, United States

    Contact

  • Site 5126

    RECRUITING

    White Plains, New York, 10605, United States

    Contact