SMOKING CESSATION

This study tests whether combining text message support for pregnant women who smoke with special training for their doctors can help them quit. About 840 women at Duke and Pitt will receive smoking cessation texts throughout pregnancy. Some doctors will also get extra training o…

This study tests a smoking cessation program called All Nations Breath of Life, designed specifically for American Indian communities. It involves 576 participants at four sites—two on reservations and two in urban areas. The program includes counseling and support, and success i…

This study tests a telephone-based version of the All Nations Breath of Life program, designed specifically for American Indians who smoke. Participants receive coaching calls over the phone and are compared to those in a general smoking cessation program. The main goal is to see…

This study tests whether the nicotine concentration in vape pods affects how well smokers can quit. 312 adult smokers who want to quit will use either low or high nicotine salt e-liquids for three months, plus receive counseling. The goal is to see if higher nicotine levels lead …

This study tests whether taking progesterone pills can prevent new mothers from relapsing into cigarette smoking after childbirth. Researchers will enroll 171 women who recently quit smoking during pregnancy to see if the hormone helps them stay smoke-free and reduces secondhand …

This study looks at whether helping both patients and their household members quit smoking together works better than helping patients alone. About 231 patients who smoke and live with other smokers will get nicotine replacement therapy and support. Researchers will check quit ra…

This study tests whether a nurse-led smoking cessation program with free drugs and follow-up at healthy life centers helps heart patients quit smoking better than just giving them written information. About 221 daily smokers hospitalized for a heart event will be split into two g…

This study looks at whether offering money can help hospitalized smokers quit. Over 1,000 adult smokers will be given different types of financial rewards to see which approach works best. The goal is to find a cost-effective way to help people stop smoking for good.

This study offers lung cancer screenings to smokers aged 50 and older who want to quit. Participants receive counseling and may also get FDA-approved smoking cessation drugs. The goal is to see which counseling approach works best for helping people stop smoking.

This study tests a proactive, culturally tailored outreach program to help BIPOC adults who smoke quit tobacco. Researchers will enroll 700 participants from two health systems and provide personalized materials and support to connect them with proven cessation treatments. The go…

This study tests whether a program combining phone counseling and personalized text messages can help 360 cervical cancer survivors in Florida quit smoking better than standard quitline services. Participants must have a history of cervical cancer or high-grade cervical dysplasia…

This study tests a new way to help informal workers (like street vendors and farmers) in Thailand quit smoking. Trained village health volunteers provide advice and support, while participants also get messages and counseling through the Line app and a telephone Quitline. The pro…

This study tests whether an electronic visit (e-visit) can help adults aged 40+ in rural areas quit smoking and get screened for COPD. Participants are randomly assigned to receive the e-visit or standard care. The e-visit is like an online questionnaire about smoking history and…

This study tests whether offering financial incentives through a mobile phone app can help low-income adults quit smoking. 532 participants will receive either standard care (phone counseling and nicotine patches/gum) or standard care plus mobile rewards for verified abstinence. …

This study tests whether a smartphone-based program can help people living with HIV quit smoking better than standard phone counseling. About 638 participants will use nicotine patches and lozenges along with either automated video coaching or traditional quitline support. The go…

This study tests whether a gamified exercise program can improve cardiorespiratory fitness and help hardcore smokers (at least 20 cigarettes a day for a year) quit. Sixty physically inactive smokers will follow a 12-week structured exercise program with game-like elements. The st…

This study tests a program to help people living with HIV in Botswana stop smoking. It combines counseling with a medication called varenicline. The goal is to see if this approach helps them quit and improves their health. The study involves 750 participants who are daily smoker…

This study compares nicotine e-cigarettes, nicotine-free e-cigarettes, and the medication varenicline to see which works best for helping people quit smoking. About 650 adult smokers who want to quit will take part. The main goal is to see who can stay away from regular cigarette…

This study tests a program called ESCAPE that combines counseling, nicotine replacement, digital videos, and lung screening education to help high-risk smokers quit. It involves 153 smokers aged 55-77 with a heavy smoking history. The program is compared to standard care (brief a…

This study tests whether mobile health support (text messages and chat-based coaching) and financial incentives (up to HK$500) can help 1200 older, low-income smokers in Hong Kong quit. Participants are aged 60+ and smoke daily. The main goal is to see if these approaches lead to…

This study looks at which treatments work best to help smokers reduce or quit smoking when they come for lung cancer screening. About 800 patients at lung cancer screening sites across the U.S. are taking part. The goal is to find a simple, effective approach that screening sites…

This trial tests whether a school-based program can help parents stop smoking. About 700 families with a smoking parent will take part. The program includes education, motivation support, and relapse prevention delivered both in person and online. Success is measured by whether p…

This study tests whether a combination of low-dose aspirin, a smoking cessation drug called cytisine, and guidance on diet and exercise can reduce chronic inflammation and lower lung cancer risk in heavy smokers aged 55 to 75. The 2000 participants will also receive annual low-do…

This study tests a mobile app called 'Forward to Quit' designed specifically for transgender adults who want to stop smoking. The app was created with input from transgender people and their doctors. Researchers want to see if the app is easy and helpful to use, and if it can hel…

This study compares a new counseling approach called Acceptance and Commitment Therapy (ACT) with standard counseling to help people with head and neck, lung, breast, gastrointestinal, or genitourinary cancer stop smoking. About 51 adults who smoke at least one cigarette per day …

This study aimed to test a new smoking cessation program for adults who identify as sexual or gender minorities and experience high social stress. The program combined standard support (behavioral counseling and nicotine replacement therapy) with remote volunteer activities to he…

This study tests whether a smartphone app designed for people with serious mental illness can help them quit smoking. About 64 adults who smoke heavily and have a mental illness will use one of two special apps or a standard app for 5 weeks. All participants also get nicotine pat…

This study tests whether telling smokers their estimated 'pulmonary age' (how old their lungs act) helps them quit. About 100 smokers aged 25+ will be randomly assigned to get their pulmonary age or not. Success is measured by a breath test at 6 months. The goal is to see if this…

This study tests whether talking to a pharmacist over the phone can help smokers quit. About 80 people who currently smoke and are in a lung cancer screening program will take part. Half will get regular phone calls from a pharmacist for 12 weeks, while the other half just fill o…

This study tests a smartphone app designed to motivate smokers who are not interested in quitting within the next 30 days. Over 14 days, the app provides counseling, education, reminders, and gamification to help users become more ready to quit. Researchers will track changes in …

This small pilot study tests whether using a mobile app can help adults quit smoking. About 24 smokers from MD Anderson's Tobacco Treatment Program will use either a positive psychology app or a relaxation app alongside their usual care. The main goal is to see how well people st…

This study tests whether a short group therapy program (CBT) can help men in prison stop smoking. 202 participants will be randomly assigned to CBT, a health education session, or a waitlist. Researchers will check if they quit by measuring carbon monoxide levels at 1 and 3 month…

This study tests a nurse-led health program for adults in a secure forensic psychiatric clinic. Fifty participants will either get usual care or also take part in two personalized health coaching sessions. The goal is to see if the program is practical and acceptable, and whether…

This study looks at how Salvation Army staff can help people who smoke learn about and use free quit-smoking services, like the Wisconsin Tobacco Quit Line. Researchers will train staff to offer a short survey that gives feedback on smoking risks and treatment options. The goal i…

This study aims to find out which health risk messages work best to encourage adults who smoke some days (but not every day) to quit completely. Researchers will test different message types—health vs. social, positive vs. negative—on 320 participants. The goal is to see which me…

This study examines how nicotine buildup in gum tissue influences the results of non-surgical periodontitis treatment. Researchers will measure nicotine and cotinine levels in the gums of 56 smokers and non-smokers with periodontitis. The goal is to understand if nicotine intoxic…

This study tests a program called ENHANCE-TTS that trains pharmacists at HIV clinics to provide tobacco treatment. Researchers will see if the program helps pharmacists offer more smoking cessation services and if it helps patients quit. About 172 people from six clinics will tak…

This study follows 100 head and neck or lung cancer patients who are current or former smokers and receive radiation therapy. Researchers track who stays smoke-free at 1, 6, and 12 months after treatment ends, and what factors help or hinder abstinence. The goal is to learn how t…

This study looks at whether giving smokers information about how smoking affects their teeth and gums can help them quit. Over 1,000 people who smoke at least 10 cigarettes a day and visit a dental clinic took part. Researchers want to find new ways to support quitting by using d…

This study tests whether giving smokers and former smokers a personalized risk report (based on clinical and genetic factors) helps doctors order lung cancer screening and helps patients follow through. About 915 participants will be randomly assigned to usual care or one of two …

This study looks at 248 lung cancer patients having surgery to see if the length of time they quit smoking before the operation affects their risk of complications like pneumonia or heart issues. Researchers compare recent quitters and long-term nonsmokers to find the best timing…