SMOKING CESSATION

This study tested whether offering smokers more frequent and personalized outreach, plus more treatment choices like nicotine patches and text support, helps more people quit compared to standard care. Over 12,000 adult smokers from 10 primary care clinics took part. The goal was…

This study tested a voluntary program to help formerly homeless adults living in supportive housing make their homes smoke-free. Researchers provided one-on-one counseling to residents and trained staff to offer smoking cessation referrals. The trial involved 452 participants acr…

This study tested whether text message reminders and rewards could help people who smoke to stick with their quitline counseling and take their medication. Twenty adults who smoked daily took part. They received a prescription for a stop-smoking drug and were referred to a quitli…

This study tested whether offering small gift cards for quitting smoking helps low-income smokers stay smoke-free. 320 uninsured or Medicaid patients received either standard care (counseling and medication) or standard care plus financial rewards for verified abstinence. The mai…

This study tested whether quitting cigarettes and e-cigarettes at the same time or one after the other is more effective. Nineteen adults who smoked and vaped received varenicline (a medication to reduce cravings) and counseling. Researchers measured abstinence and health markers…

This study tested a simple tool that helps doctors choose the right stop-smoking medicines for people living with HIV. 371 smokers from three clinics took part. The goal was to see if the tool helped more people quit smoking for at least a week.

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This study tested whether offering smokers an e-cigarette starter kit, brief advice, and a referral to stop-smoking services in the emergency department helps them quit. Nearly 1,000 adult daily smokers took part. The main goal was to see if more people stayed smoke-free for six …

This study tested a program called CEASE that helps lung cancer patients quit smoking. The program was built into regular doctor visits and included screening, counseling, and referrals. Researchers studied 263 patients to see if the program improved quit rates and how well it wo…

This study tested a program to help hospitalized smokers quit. Over 1,100 adult smokers from several hospitals received either enhanced support or basic care. The goal was to see if the enhanced program could double the number of people who quit smoking six weeks after leaving th…

This completed study tested a smartphone-based program to help 520 low-income smokers quit. Participants received nicotine patches and lozenges, plus automated app content and phone counseling. The goal was to see if this approach could boost quit rates in a hard-to-reach populat…

This pilot study tested a program called 'Nudges to Quit' that sends encouraging messages to people with serious mental illness who smoke. The goal was to see if these messages could help them start smoking cessation treatments like counseling or medication. The study involved 59…

QuitBet is a digital social game that helps people stop smoking by letting them bet $30 of their own money. Players submit daily breath tests to prove they haven't smoked. Those who succeed split the pot of money from those who fail. This study tested QuitBet in 245 adults who sm…

This study compared four different smoking cessation programs to see which one works best for underserved smokers who are getting lung cancer screening. Over 3,200 participants from four U.S. health systems took part. The goal was to help them quit smoking for at least six months…

This study looked at whether smokers who quickly respond to nicotine alternatives (like patches, e-cigarettes, or pouches) can keep smoking less or stop entirely for 6 months. 150 healthy adult smokers who reduced their smoking by at least half within 2 weeks were followed. The g…

This study tested whether taking zonisamide and bupropion together helps smokers switch completely to an e-cigarette (JUUL). 180 adult smokers who wanted to switch were given the drugs or placebos for 7 weeks while using the e-cigarette. The goal was to see if the combination mad…

This study tested whether letting cancer patients choose their own smoking cessation treatment helps them quit. 126 patients with tobacco-related cancers received either varenicline, bupropion, or nicotine patches based on their preference, plus counseling. The goal was to see if…

This study tested whether a medication called d-cycloserine, combined with using a Juul e-cigarette, helps smokers switch completely from regular cigarettes. Twenty-five adult smokers who wanted to switch took d-cycloserine daily for six weeks and used Juul as much as they liked.…

This study tested a smoking cessation program for adults living in Baltimore City public housing. The program combined remote support from specialists, access to quit-smoking medications, and on-site community leaders to help residents reduce or quit smoking. The goal was to see …

This study tested a pill called cytisinicline to help adults stop smoking. Over 800 daily smokers took the pill or a placebo for 6 or 12 weeks. The goal was to see if the pill helped them stay smoke-free, verified by breath tests. Results showed it was effective for quitting smok…

This phase 3 trial tested cytisinicline, a plant-based pill, in 792 adult smokers who wanted to quit. Participants took the pill or a placebo for 6 or 12 weeks, plus brief behavioral support. The study measured smoking abstinence using carbon monoxide tests. Results showed that c…

This study tested two approaches to help people living in public housing smoke less and reduce secondhand smoke. One approach offered one-on-one support to smokers to help them cut back or quit. The other aimed to get all residents in a building to support smoke-free rules. The s…

This study tested a new counseling method designed to prevent smoking relapse in people who had recently quit. Researchers worked with 100 ex-smokers in Hong Kong to see if the approach was practical and liked by both counselors and participants. Early results will help decide if…

This study tested a program called Comprehensive Chronic Care (CCC) that uses regular phone calls, texts, and mailings to encourage smokers to quit. Nearly 1,000 adult smokers from primary care clinics were randomly assigned to receive either CCC or standard care (one annual offe…

This completed Phase 3 study tested the long-term safety of cytisinicline, a plant-based pill, taken three times daily for 52 weeks by 479 adults who previously took part in smoking or vaping cessation trials. The main goal was to track serious side effects. Researchers hope this…

This study tested a telephone program called Be Smoke Free that uses guided imagery (a relaxation technique) to help people stop smoking. Over 1,200 daily smokers from Arizona, New York, and West Virginia took part. Participants received coaching calls and were checked at 3 and 6…

This study tested two different smoking cessation treatments in 52 adult cancer patients who had been diagnosed within the past 3 years. One group received a 12-week course of the medication varenicline plus 7 counseling calls tailored to cancer patients. The other group received…

This pilot study tested a smartphone-based program in 105 adult smokers who also used smoke-free nicotine products like e-cigarettes or nicotine pouches. The program included a breath sensor and text coaching to help them switch completely from cigarettes to these products. Resea…

This study tested four health system strategies to encourage adult smokers who weren't ready to quit to start using evidence-based treatments. The strategies included small financial rewards, personalized mailings, proactive phone calls from a tobacco care manager, and free couns…

This study tested whether personalized chat messages via WhatsApp could help people who recently quit smoking stay smoke-free. 590 participants in Hong Kong who had quit for 3 to 30 days received either standard care or additional one-on-one messaging with a trained counselor and…

This pilot study tested a smartphone app called SiS-H, designed to help people with HIV quit smoking. 66 participants were randomly assigned to use either SiS-H or a standard quit guide app. The study measured how often people used the app and how acceptable it was, rather than d…

This study tested whether a drug called isradipine, combined with virtual reality scenes of smoking, could lower cigarette cravings. 78 daily smokers took part. The goal was to see if this approach could help people quit smoking by reducing their urge to smoke when faced with tri…

This study tested whether a chatbot providing instant messaging support via WhatsApp could help adult smokers in Hong Kong quit. Over 1,000 participants received either brief advice plus chatbot support or brief advice alone. The goal was to see if the chatbot led to higher quit …

This study tested whether combining two medications, varenicline and guanfacine, helps people quit smoking better than standard treatments. 167 adult smokers who smoked at least 10 cigarettes daily took part. Researchers measured how long participants could delay their first ciga…

This study tested whether a gentle, non-invasive brain stimulation technique called tDCS could help cancer survivors who smoke feel less distressed and smoke fewer cigarettes. 43 participants used the device at home via telehealth. The main goal was to see if people found the dev…

This study tested a new type of counseling called behavioral activation problem solving (BAPS) against standard smoking cessation counseling for people with HIV in Botswana. 651 participants were split into two groups to see which approach helped more people quit smoking. The goa…

This study tested a video-based program to help university students quit smoking. Participants recorded short videos about their reasons for quitting and received feedback from researchers. The goal was to see if this approach could reduce nicotine dependence and increase motivat…

This study tested a smoking cessation program for caregivers of children admitted to American Family Children's Hospital. 23 caregivers received a 20-minute counseling session and used nicotine patches and lozenges for 2 weeks. The goal was to see if caregivers would use the prog…

This study tested a healthbot—a conversational computer program—designed to help people remember to take their varenicline (a prescription medication to help quit smoking). Researchers worked with 40 smokers in Ontario who were starting varenicline. Participants used the healthbo…

This study tested whether exenatide, a drug used for diabetes, can help people quit smoking and prevent the weight gain that often happens after quitting. 140 adults who smoked at least 5 cigarettes daily and wanted to quit took part. They received either exenatide or a placebo a…

This study tested a new way to help cancer patients quit smoking before their surgery. 282 adults with cancer or suspected cancer who smoked daily took part. Half received standard counseling and nicotine patches, while the other half also got extra rewards for staying smoke-free…

This study tested whether cytisine, a plant-based medication, is safe and helpful for quitting smoking in people who also have alcohol use disorder. Twenty adults who smoked daily and wanted to quit took part. The main goal was to see if the drug was well-tolerated and if partici…

This study tested whether transcranial magnetic stimulation (TMS) can help smokers quit by reducing cravings and preventing relapse. 88 adults who had failed previous quit attempts received daily TMS sessions for a week, followed by maintenance sessions. The goal was to see if th…

This completed study tested whether motivational interviewing, a supportive counseling style, delivered through online video calls could increase the intention to quit smoking in people with lung cancer. Forty-two participants who smoked were randomly assigned to receive the inte…

This study tested whether mailing free samples of varenicline (Chantix) or nicotine patches and lozenges helps smokers quit. 652 daily smokers were randomly assigned to receive a one-time sample of varenicline, nicotine replacement products, or no medication. Participants were no…

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This study tested whether a non-invasive brain stimulation technique called rTMS could reduce tobacco cravings in heavy smokers who had already failed multiple quit attempts. 39 highly nicotine-dependent adults received either real or fake rTMS to a brain region linked to craving…

This study tested if chewing gum can help people smoke less or quit. 80 adults in Hong Kong who wanted to quit or cut down either used chewing gum or tried to quit on their own for one week. Researchers measured how much they smoked and checked their saliva to confirm if they had…

This study tested whether higher doses of nicotine patches and lozenges help people quit both smoking and vaping. 46 adults who used both cigarettes and e-cigarettes daily took part. Researchers measured how many days they stayed away from both products and checked for side effec…

This study tested whether a chatbot could help young smokers (up to age 25) quit tobacco. Over 150 participants used the chatbot as part of a youth quitline program. Researchers checked how many joined, stayed, and found it useful, and measured quit rates with saliva tests. The g…

This study tested a smartphone app called OKquit to help smokers quit. About 500 adults who wanted to stop smoking were split into two groups: one got standard helpline support plus daily check-ins, and the other got that plus the OKquit app. The goal was to see if the app helped…

This study tested whether suvorexant, a sleep aid, could help smokers manage cravings, withdrawal, and stress that often lead to relapse. Fourteen non-treatment-seeking smokers took the drug or a placebo and were monitored for stress reactions, smoking urges, and sleep quality. T…

This pilot study tested whether watching videos about quitting smoking is acceptable and practical for cancer patients. 42 participants either received links to smoking cessation videos or a standard booklet. The study measured how much patients liked the videos and whether they …

This study tested a program to help cancer survivors quit smoking and manage pain. Nineteen survivors received counseling and the medication varenicline (Chantix). The goal was to see if the program was practical and helpful, not yet to prove it works.

This study tested a mobile app called CoQuit that uses cognitive dissonance—the mental discomfort of holding conflicting beliefs—to motivate smokers to quit. 72 adult daily smokers used the app for 25 days, completing activities like writing a letter to a young person about smoki…

This completed study examined how African American and white male smokers respond to stress and how that affects their smoking habits. Researchers used a psychological stress test and measured daily cortisol patterns to understand biological differences. The goal is to learn why …

This study tested whether showing smokers a virtual reality (VR) program during a dental cleaning appointment encourages them to use proven quit-smoking tools like counseling, nicotine patches, or text-message programs. About 440 cigarette smokers scheduled for a dental cleaning …

This study looked at whether intermittent fasting or quitting smoking can change DNA markers linked to aging and cancer risk. 156 healthy women aged 30-60 followed a 6-month program with coaching and optional exercise. Researchers measured changes in DNA methylation patterns to s…

This study looked at how a specific way of thinking, called high-level construal (focusing on the big picture), affects smoking habits. Researchers studied 300 low-income adults aged 25-55 who wanted to quit but had failed before. They used brain scans and surveys to see if this …

This study tested a volitional help sheet, a simple planning tool, to help young adults aged 20-45 in Indonesia quit smoking. Over 2700 participants used the sheet to plan how to handle situations that trigger smoking. The main goal was to see if it helped them stop smoking, and …

This study involved 60 African American menthol smokers who tried six different nicotine replacement products, including mint-flavored and non-flavored gum and inhalers. After two weeks of sampling, they chose one product to help them quit smoking for another two weeks. The goal …

This completed study looked at 1029 patients who had a heart attack or unstable angina and quit smoking. Researchers checked for certain gene mutations (called CHIP) in their blood. They wanted to see if these mutations are linked to a higher chance of future heart problems, like…

This study tested whether different nicotine concentrations in e-cigarettes (5% vs 1.8%) change how much smokers puff, how much nicotine they get, and whether they switch completely from cigarettes. Fifty-two Black and white smokers who wanted to switch to e-cigarettes for 6 week…