Quit smoking and vaping together or one at a time? small study seeks answers

NCT ID NCT06027840

Completed Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether quitting cigarettes and e-cigarettes at the same time or one after the other is more effective. Nineteen adults who smoked and vaped received varenicline (a medication to reduce cravings) and counseling. Researchers measured abstinence and health markers at 12 weeks. The goal is to find the best strategy for dual users to quit both products.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Varenicline (a medication to reduce cravings) and behavioral counseling
What this could lead to: If successful, this could help people who both smoke and vape find the best way to quit both products for good.
What could go wrong: This is a very small, early-phase study with only 19 participants, so results may not apply to everyone. The medication varenicline can cause side effects like nausea or sleep issues.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking Smoking Cessation Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIGARETTE SMOKING E-CIGARETTE USE SMOKING CESSATION

Contacts and locations

Locations

Yale University

New Haven, Connecticut, 06520, United States

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