E-Cig nicotine levels may influence how much smokers puff and switch

NCT ID NCT05887947

Completed Knowledge-focused Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether different nicotine concentrations in e-cigarettes (5% vs 1.8%) change how much smokers puff, how much nicotine they get, and whether they switch completely from cigarettes. Fifty-two Black and white smokers who wanted to switch to e-cigarettes for 6 weeks took part. Researchers measured puffing patterns and smoking status to see if nicotine strength helps people quit smoking.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Electronic cigarette with 5% or 1.8% nicotine concentration (Vuse Alto)
What this could lead to: If it works, this could help design better e-cigarettes to help people switch away from smoking tobacco cigarettes.
What could go wrong: This was a small, completed study with only 52 people, so results may not apply to everyone. E-cigarettes still carry health risks and are not proven safe for quitting smoking.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING CESSATION

Contacts and locations

Locations

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

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