Can a TB drug help smokers kick the habit with E-Cigs?

NCT ID NCT05994703

Completed Disease control Sponsor: Rose Research Center, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a medication called d-cycloserine, combined with using a Juul e-cigarette, helps smokers switch completely from regular cigarettes. Twenty-five adult smokers who wanted to switch took d-cycloserine daily for six weeks and used Juul as much as they liked. The goal was to see if this approach could speed up learning new habits and reduce smoking.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: d-cycloserine (a medication) and Juul e-cigarette
What this could lead to: If it works, this could point toward a new way to help smokers switch to e-cigarettes and reduce harm from smoking.
What could go wrong: This is a very small, early Phase 2 trial with only 25 people. The results may not apply to everyone, and d-cycloserine can cause side effects like dizziness or drowsiness.

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Conditions

The condition(s) this trial relates to.

Harm Reduction Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HARM REDUCTION SMOKING CESSATION

Contacts and locations

Locations

Rose Research Center

Charlotte, North Carolina, 28262, United States
Rose Research Center

Raleigh, North Carolina, 27617, United States

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