New pill helps smokers kick the habit in major trial

NCT ID NCT05206370

Completed Disease control Sponsor: Achieve Life Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested cytisinicline, a plant-based pill, in 792 adult smokers who wanted to quit. Participants took the pill or a placebo for 6 or 12 weeks, plus brief behavioral support. The study measured smoking abstinence using carbon monoxide tests. Results showed that cytisinicline helped more people quit smoking compared to placebo, offering a potential new option for smoking cessation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cytisinicline (also known as cytisine), a plant-based pill to reduce nicotine cravings
What this could lead to: If successful, this could provide a new, affordable, and effective medication to help people quit smoking, reducing smoking-related diseases.
What could go wrong: This is a completed phase 3 trial, but results may not apply to all smokers. Long-term abstinence beyond 24 weeks is not yet confirmed, and side effects like nausea or insomnia are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SMOKING CESSATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING CESSATION

Contacts and locations

Locations

Accel Research Sites - DeLand Clinical Research Unit

DeLand, Florida, 32720, United States
Affinity Health Corp

Oak Brook, Illinois, 60523, United States
Alliance for Multispecialty Research, LLC

Fort Myers, Florida, 33912, United States
Aventiv Research Inc

Columbus, Ohio, 43212, United States
Clinical Research Associates, Inc.

Nashville, Tennessee, 37203, United States
Global Medical Institutes LLC; Princeton Medical Institute

Princeton, New Jersey, 08540, United States
Health Research of Hampton Toads, Inc

Newport News, Virginia, 23606, United States
Intend Research

Norman, Oklahoma, 73069, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
MediSphere Medical Research Center, LLC

Evansville, Indiana, 47714, United States
Trial Management Associates, LLC

Wilmington, North Carolina, 28403, United States
Velocity Clinical Research, Inc.

Cleveland, Ohio, 44122, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.