Can a drug combo help smokers ditch cigarettes for E-Cigs?

NCT ID NCT05205811

Completed Disease control Sponsor: Rose Research Center, LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking zonisamide and bupropion together helps smokers switch completely to an e-cigarette (JUUL). 180 adult smokers who wanted to switch were given the drugs or placebos for 7 weeks while using the e-cigarette. The goal was to see if the combination made it easier to stop smoking regular cigarettes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zonisamide and bupropion (drugs)
What this could lead to: If it works, this could point toward a new medication combination to help smokers switch to less harmful e-cigarettes.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The study only tested switching to a specific e-cigarette, so findings may not apply to all smokers or devices.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Smoking Cessation Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING CESSATION

Contacts and locations

Locations

Rose Research Center

Charlotte, North Carolina, 28262, United States
Rose Research Center

Raleigh, North Carolina, 27617, United States

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