New pill shows promise for Long-Term smoking and vaping cessation
NCT ID NCT06435221
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 3 study tested the long-term safety of cytisinicline, a plant-based pill, taken three times daily for 52 weeks by 479 adults who previously took part in smoking or vaping cessation trials. The main goal was to track serious side effects. Researchers hope this drug could offer a safe, long-term option to help people quit nicotine products.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cytisinicline (also known as cytisine) 3 mg tablets taken three times daily
What this could lead to
If successful, this could confirm that long-term use of cytisinicline is safe, supporting its approval as a treatment to help people quit smoking or vaping.
What could go wrong
This is a safety study, not designed to prove effectiveness. Side effects or serious adverse events may still emerge, and results may not apply to all smokers or vapers.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Accel Research Sites Network - DeLand Clinical Research Unit
DeLand, Florida, 32720, United States
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Alliance for Multispecialty Research, LLC
Mobile, Alabama, 36608, United States
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Alliance for Multispecialty Research, LLC
Tempe, Arizona, 85281, United States
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Alliance for Multispecialty Research, LLC
Coral Gables, Florida, 33134, United States
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Alliance for Multispecialty Research, LLC
Fort Myers, Florida, 33912, United States
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Alliance for Multispecialty Research, LLC
Oak Brook, Illinois, 60523, United States
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Alliance for Multispecialty Research, LLC
Wichita, Kansas, 67207, United States
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Alliance for Multispecialty Research, LLC
Lexington, Kentucky, 40509, United States
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Alliance for Multispecialty Research, LLC
New Orleans, Louisiana, 70119, United States
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Alliance for Multispecialty Research, LLC
Kansas City, Missouri, 64114, United States
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Alliance for Multispecialty Research, LLC
Las Vegas, Nevada, 89119, United States
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Alliance for Multispecialty Research, LLC
Norman, Oklahoma, 73069, United States
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Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, 37909, United States
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Alliance for Multispecialty Research, LLC
Norfolk, Virginia, 23502, United States
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Altoona Center for Clinical Research
Duncansville, Pennsylvania, 16635, United States
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Centricity Research Columbus Ohio Multispecialty
Columbus, Ohio, 43213, United States
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Clinical Research Associates, Inc.
Nashville, Tennessee, 37203, United States
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Clinical Research Atlanta
Stockbridge, Georgia, 30281, United States
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Clinical Trials of Texas, LLC
San Antonio, Texas, 78229, United States
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Coastal Carolina Research Center
North Charleston, South Carolina, 29405, United States
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Global Medical Institutes LLC; Princeton Medical Institute
Princeton, New Jersey, 08540, United States
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Health Research of Hampton Roads, Inc.
Newport News, Virginia, 23606, United States
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Insight Research Institute
Flint, Michigan, 48507, United States
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Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
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Little Rock Allergy & Asthma Clinical Research Center
Little Rock, Arkansas, 72205, United States
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Massachusetts General Hospital - Clinical Genetic Facility
Boston, Massachusetts, 02114, United States
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MediSphere Medical Research Center, LLC
Evansville, Indiana, 47714, United States
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Precision Clinical Research
Sunrise, Florida, 33351, United States
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Rochester Clinical Research, LLC
Rochester, New York, 14609, United States