New pill shows promise for Long-Term smoking and vaping cessation

NCT ID NCT06435221

Completed Disease control Sponsor: Achieve Life Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 3 study tested the long-term safety of cytisinicline, a plant-based pill, taken three times daily for 52 weeks by 479 adults who previously took part in smoking or vaping cessation trials. The main goal was to track serious side effects. Researchers hope this drug could offer a safe, long-term option to help people quit nicotine products.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cytisinicline (also known as cytisine) 3 mg tablets taken three times daily
What this could lead to: If successful, this could confirm that long-term use of cytisinicline is safe, supporting its approval as a treatment to help people quit smoking or vaping.
What could go wrong: This is a safety study, not designed to prove effectiveness. Side effects or serious adverse events may still emerge, and results may not apply to all smokers or vapers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING CESSATION VAPING CESSATION

Contacts and locations

Locations

Accel Research Sites Network - DeLand Clinical Research Unit

DeLand, Florida, 32720, United States
Alliance for Multispecialty Research, LLC

Mobile, Alabama, 36608, United States
Alliance for Multispecialty Research, LLC

Tempe, Arizona, 85281, United States
Alliance for Multispecialty Research, LLC

Coral Gables, Florida, 33134, United States
Alliance for Multispecialty Research, LLC

Fort Myers, Florida, 33912, United States
Alliance for Multispecialty Research, LLC

Oak Brook, Illinois, 60523, United States
Alliance for Multispecialty Research, LLC

Wichita, Kansas, 67207, United States
Alliance for Multispecialty Research, LLC

Lexington, Kentucky, 40509, United States
Alliance for Multispecialty Research, LLC

New Orleans, Louisiana, 70119, United States
Alliance for Multispecialty Research, LLC

Kansas City, Missouri, 64114, United States
Alliance for Multispecialty Research, LLC

Las Vegas, Nevada, 89119, United States
Alliance for Multispecialty Research, LLC

Norman, Oklahoma, 73069, United States
Alliance for Multispecialty Research, LLC

Knoxville, Tennessee, 37909, United States
Alliance for Multispecialty Research, LLC

Norfolk, Virginia, 23502, United States
Altoona Center for Clinical Research

Duncansville, Pennsylvania, 16635, United States
Centricity Research Columbus Ohio Multispecialty

Columbus, Ohio, 43213, United States
Clinical Research Associates, Inc.

Nashville, Tennessee, 37203, United States
Clinical Research Atlanta

Stockbridge, Georgia, 30281, United States
Clinical Trials of Texas, LLC

San Antonio, Texas, 78229, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States
Global Medical Institutes LLC; Princeton Medical Institute

Princeton, New Jersey, 08540, United States
Health Research of Hampton Roads, Inc.

Newport News, Virginia, 23606, United States
Insight Research Institute

Flint, Michigan, 48507, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
Little Rock Allergy & Asthma Clinical Research Center

Little Rock, Arkansas, 72205, United States
Massachusetts General Hospital - Clinical Genetic Facility

Boston, Massachusetts, 02114, United States
MediSphere Medical Research Center, LLC

Evansville, Indiana, 47714, United States
Precision Clinical Research

Sunrise, Florida, 33351, United States
Rochester Clinical Research, LLC

Rochester, New York, 14609, United States

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