Could a natural hormone beat menopause depression?
NCT ID NCT03505905
First seen Jan 23, 2026 · Last updated Jun 09, 2026 · Updated 20 times
Summary
This study tested whether a natural brain chemical called pregnenolone can help reduce depression in women going through menopause or perimenopause. 73 women took either pregnenolone or a placebo for a set time. Researchers measured changes in mood, anxiety, thinking, and quality of life to see if the treatment worked better than a dummy pill.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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