Could a brain steroid ease menopause depression?
NCT ID NCT03505905
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a natural substance called pregnenolone can help reduce depression in women going through menopause or perimenopause. 73 women took either pregnenolone or a placebo for several weeks. Researchers measured changes in mood, anxiety, thinking, and quality of life to see if the treatment worked better than placebo.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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