Radiation 'Re-Priming' could supercharge CAR-T therapy in stubborn lymphoma
NCT ID NCT04601831
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding focused radiation to leftover cancer spots can improve outcomes for people with non-Hodgkin lymphoma whose tumors didn't fully respond to CAR-T cell therapy. Fourteen adults received radiation to those remaining areas. The goal was to see if this combination is safe and helps more patients achieve a complete response by day 90 after CAR-T.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
focal radiation therapy
What this could lead to
If successful, this approach could help more patients achieve complete remission after CAR-T therapy, potentially improving long-term outcomes for hard-to-treat lymphoma.
What could go wrong
This is a small, early-phase trial with only 14 participants, so results may not apply broadly. Radiation carries risks like skin burns, pneumonitis, or other side effects, and the added benefit over CAR-T alone is uncertain.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States