Ketamine infusions could help curb meth addiction, new trial hopes

NCT ID NCT06496750

Ongoing Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 12, 2026 · Updated 6 times

Summary

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more participants have drug-free urine tests after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine
What this could lead to: If it works, this could point toward a new treatment option for methamphetamine use disorder, helping people reduce or stop use.
What could go wrong: This is an early phase 2 trial with only 120 people, so results may not apply broadly. Ketamine can cause side effects like dissociation or blood pressure changes, and the benefit over placebo is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amphetamine abuse methamphetamine dependence substance abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METHAMPHETAMINE ABUSE SUBSTANCE USE SUBSTANCE USE DISORDERS

Contacts and locations

Locations

Addiction Institute of Mount Sinai

New York, New York, 10029, United States
Alameda Health System

San Leandro, California, 94578, United States
Interdisciplinary Substance Use and Brain Injury Facility

Albuquerque, New Mexico, 87106, United States
Prisma Health

Greenville, South Carolina, 29617, United States
UT Southwestern Medical Center

Dallas, Texas, 75247, United States

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