Can a targeted drug beat standard care for hard-to-treat psychosis?
NCT ID NCT04580134
First seen Feb 06, 2026 · Last updated Apr 29, 2026 · Updated 12 times
Summary
This study compares clozapine to risperidone in 320 adults with schizophrenia, schizoaffective disorder, or bipolar I with psychosis. Participants are grouped by a biological subtype (Biotype-1 or Biotype-2) to see if clozapine works better for certain brain types. The main goal is to measure symptom changes over 18 weeks.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hartford Healthcare
RECRUITINGHartford, Connecticut, 06106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75235, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Chicago
RECRUITINGChicago, Illinois, 60615, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Georgia
RECRUITINGAthens, Georgia, 30602, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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