SCHIZOAFFECTIVE DISORDER

This study tests whether the antipsychotic clozapine works better than risperidone for people with schizophrenia, schizoaffective disorder, or bipolar I with psychosis, based on a specific brain biotype (B1). About 524 adults will be randomly assigned to receive either drug for 1…

This study tests magnetic seizure therapy (MST) as a gentler alternative to electroconvulsive therapy (ECT) for people with schizophrenia that hasn't improved with medication. About 80 adults with treatment-resistant schizophrenia or schizoaffective disorder will receive MST to s…

This study tests whether clozapine, a medication for schizophrenia, can lower the risk of violent acts better than other antipsychotics. About 280 adults with schizophrenia or schizoaffective disorder who have been violent in the past six months will take either clozapine or thei…

This study is testing whether a daily synbiotic supplement (a mix of probiotics and prebiotics) can reduce symptoms of schizophrenia when taken alongside standard antipsychotic medications. Researchers will compare the supplement to a placebo in 68 adults with schizophrenia or sc…

This study tests a therapy called Targeted Cognitive Training (TCT) for 80 veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses computer exercises to improve how the brain processes sounds and information, aiming to boost thinking, daily …

This study tests a smartphone app called Kiso Mind for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app plus their usual care, or just usual care. The goal is to see if the app is easy to use and if it helps with symptoms and da…

This study tests whether physical activity in green outdoor spaces reduces negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia more than indoor exercise. 45 adults aged 18-55 with persistent negative symptoms will participate. Researchers…

This study tests a smartphone app called mSITE that encourages people with schizophrenia or schizoaffective disorder to have more social interactions. Researchers will track participants' social activity and symptoms over time. The goal is to see if the app helps reduce social wi…

This study looks at whether stopping unnecessary anticholinergic drugs (like benztropine) can boost thinking, daily function, and quality of life in people aged 40-70 with schizophrenia or schizoaffective disorder. About 105 participants will either stay on their medication or sl…

This study tests whether a prebiotic (a type of fiber that feeds good gut bacteria) can reduce inflammation and improve thinking and memory in people with schizophrenia or schizoaffective disorder. Researchers will enroll 60 adults who are stable on antipsychotic medication. The …

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce symptoms like psychosis, depression, and mania in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alo…

This study looks at 320 people who recently developed a psychotic disorder (like schizophrenia or bipolar I). Researchers will use brain scans, eye-tracking, and genetic tests to see if they can predict who will respond best to treatment. Participants attend four visits over one …

This study tests a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants more accurately judge their own skills. Researchers want to see if this improves h…

This study looks at whether adding five extra services—like peer support, digital outreach, and family therapy—to standard care helps people with early psychosis stay in treatment longer. About 350 participants will either get standard care or standard care plus these extras. Res…

This study looks at how attention and thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to those without. Participants will complete computer gambling tasks during brain scans and eye-tracking, and a…

This study explores whether a non-invasive magnetic brain stimulation technique (TMS) can temporarily improve how quickly people with psychotic disorders (like schizophrenia or bipolar) solve problems. About 95 participants will do thinking tasks and get brain scans before and af…