SCHIZOAFFECTIVE DISORDER

This study tested whether adding a medication to targeted cognitive training (brain exercises) could improve thinking and daily life skills in people with schizophrenia or schizoaffective disorder. 68 adults completed the study, which measured symptoms, thinking abilities, and da…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

This early-stage study tested a long-acting injectable form of the drug lumateperone in 52 adults with stable schizophrenia or schizoaffective disorder. The goal was to see how the body processes the drug and whether it is safe and tolerable. Participants received a single shot, …

This study tested whether delivering coordinated specialty care (CSC) via telehealth helps young people (ages 16-35) with early psychosis stay engaged in treatment and avoid hospital stays. 74 participants were randomly assigned to receive care either through video visits or in-p…

This study looked at how well valbenazine works for tardive dyskinesia, a condition causing uncontrollable movements often linked to psychiatric medications. 59 adults with schizophrenia, bipolar disorder, or depression took valbenazine for up to 24 weeks. Researchers measured ch…

This study tested whether luteolin, a natural substance found in celery, green pepper, and chamomile tea, can improve symptoms of schizophrenia. 85 adults with schizophrenia or schizoaffective disorder took either luteolin or a placebo. The goal was to see if luteolin reduces ove…

This study tested a visual training program for 79 adults with schizophrenia or schizoaffective disorder. The program aimed to improve two visual skills often impaired in these conditions: seeing contrast and organizing visual information. Participants completed exercises targeti…

This study tested whether adding the drug memantine to a computer-based cognitive training program improves thinking and daily function in people with schizophrenia or schizoaffective disorder. 62 adults took part in a double-blind trial where some received memantine plus trainin…

This study tested an investigational medication called BXCL501 for calming agitation episodes in people with schizophrenia or bipolar disorder. The medication was designed to be taken at home. 452 adults took part, and the drug was compared to a placebo (a dummy pill). The goal w…

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This study tested whether a smartphone app could passively track activity, sociability, and sleep in 87 veterans with serious mental illnesses like schizophrenia and bipolar disorder. The goal was to see if phone data could detect early warning signs of worsening symptoms. The st…

This large study from the National Institute of Mental Health looks at how genes and brain function work together in people with schizophrenia and their siblings. The goal is to find the genes that increase risk and understand how they affect the brain. Nearly 5,000 participants …

This study looked at how people aged 18-30 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Participants completed computer-based tasks and cognitive training. The goal was to better understand thinking patterns…

This study tested whether patients with schizophrenia or schizoaffective disorder could gain better insight into their illness by watching a video of themselves recorded during an acute episode. 60 hospitalized patients were randomly assigned to either watch the video after stabi…

This study looked at how certain brain receptors (dopamine D1 and D2/3) work in people with schizophrenia compared to healthy volunteers. Researchers used special brain scans (PET and MRI) to measure these receptors. The goal was to better understand what causes schizophrenia, wh…

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness, like schizophrenia, work together with their doctors on treatment choices. Thirty-nine veterans took part in a small trial to see if the training was pra…

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Researchers tested two types of cognitive training and measured changes in thinking skills and brain activity using com…

This study looked at how the supplement N-acetylcysteine (NAC) affects brain chemicals and thinking in 88 people with schizophrenia. Participants took tryptophan to raise a brain chemical called kynurenic acid, then received either NAC or a placebo. Researchers used memory tests …

This study tested whether sending text message reminders helps young people (ages 14-35) with psychosis attend their first appointment at an early psychosis clinic after being seen in the emergency room. Researchers enrolled 186 participants and tracked who showed up. The goal wa…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study tested whether customizing cognitive training based on a person's early auditory processing ability improves thinking and daily function in people with schizophrenia or schizoaffective disorder. 194 participants were grouped by their auditory processing skill and then …