University Of Texas Southwestern Medical Center

This study tests whether Tofacitinib, a drug used for arthritis, can slow tumor growth in people with recurrent glioblastoma (a type of brain cancer). About 17 adults whose cancer returned after standard treatment will take Tofacitinib pills twice daily. The goal is to see if it …

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This study tested magnetic seizure therapy (MST) in 239 adults with treatment-resistant depression to see if it works as well as electroconvulsive therapy (ECT) but with fewer memory side effects. MST uses magnetic pulses to trigger a controlled seizure, aiming to relieve depress…

This study tested whether adding an immunotherapy drug called APX005M to standard treatment helps people with advanced rectal cancer achieve a complete response (no cancer left after treatment). 58 adults with stage II or III rectal cancer at high risk took part. The goal was to …

This study tested whether adding lower leg heat therapy (soaking legs in warm water) to a standard blood pressure pill helps older women with high blood pressure more than the pill alone. 134 women aged 60-85 participated, either soaking in 42°C water or neutral 33°C water for 8 …

This study tested whether real-time remote blood sugar monitoring and secure texting could help teens (ages 13-18) with poorly controlled type 1 diabetes improve their blood sugar levels. Twenty teens wore a continuous glucose monitor that shared their readings with the study tea…

This study tested a new way to give radiation for head and neck cancer. Instead of treating the whole neck, doctors used artificial intelligence to focus radiation only on the cancer spots. 67 patients took part to see if this approach could reduce side effects without increasing…

This study tested whether Tenapanor, a drug approved for kidney disease, can reduce oxalate absorption from food and lower the risk of kidney stones. Eighteen healthy adults without a history of stones took the drug or a placebo, and their urine oxalate levels were compared. The …

This completed early-phase trial tested whether switching HIV medications to doravirine (with emtricitabine and tenofovir alafenamide) could improve cholesterol and reduce early signs of artery hardening compared to staying on integrase inhibitors. Twenty-six adults with well-con…

This study looked at 25 kidney transplant patients to see if a blood test measuring donor DNA could help them safely reduce their immunosuppressant medications to just one drug, belatacept. The goal was to see if this approach could prevent kidney rejection while simplifying trea…

This study tested a method called LISA (Less Invasive Surfactant Administration) in extremely preterm infants (22-25 weeks). Instead of inserting a breathing tube, doctors gave lung medication through a thin catheter while the baby continued on CPAP. The goal was to see if this a…

This study tested a remote video monitoring system to help people with opioid use disorder safely take their methadone at home. Fifteen adults already on methadone treatment used a smartphone or computer camera to record each dose. The goal was to see if this method could track a…

This study tested whether taking a daily probiotic supplement could prevent relapse in people recently hospitalized for mania. Over 24 weeks, 66 participants received either the probiotic or a placebo. The main goal was to see if the probiotic reduced the need for re-hospitalizat…

This early-phase study tested a shorter, more intense radiation schedule (completed in 3 weeks instead of the usual 6) combined with chemotherapy for people with HPV-related throat cancer. The goal was to find the safest dose that still controls the cancer. Only 24 patients took …

This study tested whether a single daily pill containing three heart failure drugs could help people with reduced ejection fraction, especially those with low income or from minority groups. 212 adults took either the polypill or standard separate medications. The goal was to see…

This study looked at whether giving heart failure patients either medically tailored meals or fresh produce boxes after a hospital stay could improve their health and reduce return visits to the hospital. 150 adults who had been hospitalized for heart failure were randomly assign…

This study tested whether a combination of two extended-release medications (naltrexone and buprenorphine) could help adults reduce cocaine use. Over 400 people who wanted to cut back or quit cocaine took part. The approach uses monthly injections to manage cravings and use, aimi…

This study tested whether adding focused radiation to leftover cancer spots can improve outcomes for people with non-Hodgkin lymphoma whose tumors didn't fully respond to CAR-T cell therapy. Fourteen adults received radiation to those remaining areas. The goal was to see if this …

This study looked at 205 pairs of caregivers with major depression and their children (ages 7-17) with asthma. Caregivers could choose to take standard antidepressant medication or not. Researchers tracked changes in the caregiver's depression and the child's asthma control over …

This study tested a program called Walk Together, which helps African American adults with high blood pressure and their family members work as a team to manage the condition. The program included training on using a blood pressure cuff, setting health goals, and improving commun…

This study tested whether the diabetes drug pioglitazone, weight loss, or both can help prevent uric acid kidney stones in overweight people. Twenty-nine participants were randomly assigned to one of three groups for 24 weeks. The main goal was to see if these interventions could…

This pilot study tested whether a gentle brain stimulation technique called HD-tDCS could improve memory and word recall in 27 older adults with mild cognitive impairment. Participants received either real or sham stimulation over 10 sessions across two weeks. The goal was to see…

This study tested a new type of radiation therapy that adjusts the treatment beam each day based on the patient's current anatomy. The goal was to see if this daily adaptive approach could reduce chronic dry mouth (xerostomia) compared to standard radiation in 50 people with head…

This study tested whether giving two medicines (atropine and fentanyl) before a less invasive breathing treatment helps preterm babies have fewer dangerous drops in heart rate and oxygen levels. Fifty-eight babies born at 29 weeks or later took part. The goal is to see if premedi…

This phase II trial tested an interactive movie system called PROMISE to help children aged 3-11 stay still during radiation therapy for cancer, aiming to reduce the need for general anesthesia. The study enrolled 30 children and compared the rate of anesthesia use to a historica…

This study tested a combination of light and laser treatments on 15 adults with skin pigmentation and texture issues from sun damage. Participants received up to two treatments using the Sciton Joule System, which combines broad-based light, fractionated laser, and dual-wavelengt…

This study tested whether a natural substance called pregnenolone can help reduce depression in women going through menopause or perimenopause. 73 women took either pregnenolone or a placebo for several weeks. Researchers measured changes in mood, anxiety, thinking, and quality o…

This study tested whether a device that delivers a very mild electrical current to the scalp could improve memory in 26 older adults with mild cognitive impairment and a past traumatic brain injury. Participants received ten sessions of either real or fake stimulation to a brain …

This study tested a 10-session therapy program delivered by phone or video to help adults with moderate-to-severe depression become more physically active. The goal was to see if the program was practical and liked by participants, and if it could reduce depressive symptoms. 65 a…

This study tested a special laser (1927nm) to reduce dark spots on the face in 15 adults with Fitzpatrick Skin Types V and VI (darker skin). The goal was to see if the laser works and to find the best skin care routine before and after treatment to avoid side effects like scarrin…

This study looked at whether a higher daily dose of vitamin D (4000 IU) is better than the standard dose (400 IU) for adults who had a major burn injury and are vitamin D deficient. 48 people took part, and researchers measured changes in their physical and mental health, as well…

This study tested whether ketamine, a fast-acting drug, can reduce suicidal thoughts in teenagers more quickly than standard treatments. Fifty teens aged 13-18 who had recent suicidal events received either ketamine or midazolam twice weekly for two weeks, then were monitored for…

This completed Phase I safety trial tested whether using the UroLift system—a device that lifts and holds enlarged prostate tissue out of the way—before stereotactic ablative body radiotherapy (SABR) is safe for men with both prostate cancer and benign prostatic hyperplasia (BPH)…

This small pilot study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could help people with persistent symptoms after a mild concussion. Twelve adults who had symptoms for 3 to 12 months after their injury received either real or fake (…

This study looked at whether adding a nerve block in the armpit to the standard shoulder block can reduce pain and opioid use after total shoulder replacement. Twelve adults having shoulder replacement surgery received both blocks. Researchers measured recovery room time, pain sc…

This study looked at whether spraying water on the skin can help burn survivors keep their body temperature down during exercise in hot conditions. Researchers compared core and skin temperature changes in 31 participants (burn survivors and healthy controls) while they exercised…

This study looked at why people with a certain type of heart failure (HFpEF) have trouble exercising and feel short of breath. Researchers tested whether different exercise programs (using the whole body or just one leg) could improve fitness. The study involved 93 adults aged 60…

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This study tested a virtual reality simulator (VLaHHS) designed to train general surgery residents on laparoscopic hiatal hernia repair. Eight residents practiced on the simulator for up to 15 sessions over three weeks. Researchers measured their skill improvement and whether the…

This study looked at 29 children with brain injuries to test two new methods for checking how well the brain controls its own blood flow. The goal was to see if these methods could help doctors better understand and treat brain injuries. The study did not test a treatment, but ai…

This study looked at 86 people with very high or very low cholesterol efflux—a measure of how well the body removes cholesterol from cells. Researchers analyzed their genes, proteins, and lipids to find clues that could lead to new ways to prevent or reverse heart disease. The go…

This study looked at how radiofrequency ablation (using heat) affects adenomyosis tissue in 15 women who were already scheduled for a hysterectomy. The goal was to see how well the treatment destroys the abnormal tissue by examining it under a microscope after surgery. The study …

This completed Phase 2 trial enrolled 61 postmenopausal women with operable, hormone-sensitive breast cancer. Participants took letrozole for 7 to 30 days before their scheduled surgery. The goal was to measure changes in a tumor marker called Ki67 to see which cancers are highly…

This study looked at how blood pressure medications affect brain blood flow and the nervous system in older adults with high blood pressure. Researchers gave 27 participants either a drug or a placebo for 1-2 weeks and measured brain blood flow, cognitive function, and nerve acti…

This study looked at how natural changes in sex hormones (like estrogen and progesterone) during the menstrual cycle affect muscle reflexes and brain signals in women. Researchers tested 102 healthy women and men using simple muscle and brain measurements. The goal was to underst…

This study interviewed 15 children aged 12 to 21 who have bleeding or clotting disorders. Researchers asked about their quality of life, confidence in managing their condition, and how they view the care they receive. The goal is to better understand the real-life challenges thes…

This study brought together 50 international experts to agree on what training doctors need to safely place breathing tubes in critically ill patients. Using a structured method called Delphi, the experts voted on key training topics until they reached strong agreement. The goal …

This study looked for proteins in the blood that might predict how well liver cancer treatments work. Researchers took blood samples from 17 patients before and after standard treatments like TACE or ablation. The goal was to find biomarkers that could help doctors choose the bes…

This study looked at 101 adults having elective spine surgery to compare two medicines (norepinephrine and phenylephrine) used to keep blood pressure stable during the operation. The main goal was to see how much of each drug was needed. Researchers also checked if either drug le…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This study looked at whether inflammation in the body is linked to suicidal thoughts and behaviors in teenagers. Researchers took blood samples and surveyed 225 teens aged 12-18, including those with recent suicidal behavior, those at risk for depression, and healthy controls. No…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and brain areas involved in learning. Researchers gave 66 healthy adults and people with depression either the steroid or a placebo for three days, then used memory tests and advanced MRI s…

This study tested a special vest designed to protect central venous catheters (CVCs) in children aged 0-12. Researchers wanted to see if the vest was practical and how satisfied parents and nurses were with it. 30 children participated, and parents and nurses provided feedback th…

This study looked at how heat waves impact the heart and body temperature in healthy older adults (65+) compared to younger people. Researchers measured core body temperature and heart function during simulated heat wave conditions. The goal was to understand the risks so we can …

This study created a registry of 149 cancer patients who received a precise type of radiation called SBRT. The goal was to track how doctors use this treatment in four different situations: for cancer that has spread to a few spots, after chemotherapy, before starting chemotherap…

This study looked at whether mailing at-home genetic testing kits to relatives of people with hereditary cancer gene variants could increase the number of relatives who get tested. Researchers compared this approach to usual care in 108 participants. The goal was to see if making…