University Of Texas Southwestern Medical Center

This study tested the safety of combining two treatments for men who have both prostate cancer and an enlarged prostate (BPH). First, doctors implanted a small device (UroLift) to relieve urinary symptoms. Then, patients received a short, precise course of radiation (SAbR) to tre…

This study looked at whether switching to a specific HIV medication called doravirine could be better for heart health compared to other common HIV drugs. It involved 26 adults with stable, treated HIV and high cholesterol. Researchers measured cholesterol function and markers li…

This study tested if a simple, at-home therapy—soaking the lower legs in warm water—could help control high blood pressure in older women when used alongside a standard blood pressure pill. Researchers enrolled 134 women aged 60-85 and compared those who did warm water soaks to a…

This study tested whether giving a lung-soothing medicine called surfactant immediately in the delivery room, using a thin tube instead of a breathing machine, could help extremely premature babies breathe better. It compared this early approach to the standard method of giving t…

This study tested whether adding targeted radiation could help patients with aggressive lymphoma who didn't fully respond to CAR-T cell therapy. Researchers gave radiation to the remaining cancer spots in 14 patients about a month after their CAR-T treatment. They wanted to see i…

This study tested whether taking probiotic supplements could help prevent people from being re-hospitalized for mania after being discharged. Sixty-seven people recently hospitalized for mania were randomly assigned to take either probiotic capsules or placebo pills for 24 weeks.…

This study tested a new program called 'Walk Together' that involves family members to help African American adults better manage their high blood pressure. The program focused on lifestyle changes like diet and exercise, with family support as a key component. Researchers wanted…

This study tested whether a drug called Tenapanor could reduce the body's absorption of oxalate, a substance that can form painful kidney stones. Eighteen healthy adults ate a high-oxalate diet and took either the drug or a placebo for short periods while researchers measured oxa…

This study tested whether kidney transplant patients could safely switch from taking several anti-rejection medications to just one drug called belatacept. Researchers used special blood tests to monitor patients for signs of organ rejection during this medication change. The goa…

This study tested a new way to deliver radiation therapy for head and neck cancer. Doctors used artificial intelligence (AI) tools to focus radiation only on cancerous lymph nodes, instead of treating large areas of the neck. The goal was to see if this more precise method could …

This study tested if having doctors remotely monitor teens' continuous blood sugar data in real-time could help improve their diabetes control. Twenty teenagers with poorly managed type 1 diabetes wore a sensor that sent glucose readings to the study team via smartphone for three…

This study tested whether providing 90 days of healthy food to heart failure patients after a hospital stay could improve their health and prevent return trips to the hospital. Researchers compared giving medically tailored meals, fresh produce boxes, or no food support to 150 pa…

This study tested a new video monitoring system for people taking methadone at home to treat opioid addiction. The goal was to see if this remote method could make treatment safer by ensuring the medication is taken correctly and not misused, while also making it more convenient …

This study tested a special wearable vest designed to protect central line catheters in children. Researchers wanted to see if using the vest was practical and to measure how satisfied parents and nurses were with it. They interviewed parents and collected survey feedback over se…

This study tested if a diabetes medication (pioglitazone) and weight loss could help control uric acid kidney stones. Researchers compared the drug, a weight loss program, and their combination in 29 overweight patients over 24 weeks. The main goal was to see if these treatments …

This study tested a new type of radiation therapy that adapts the treatment plan each day based on the patient's current anatomy. The goal was to better target the cancer while reducing radiation exposure to nearby healthy organs, like the salivary glands, to lessen side effects …

This study tested whether a single daily pill containing three proven heart failure medications works better than giving the medications separately. It focused on low-income and racially diverse patients who often face barriers to getting optimal care. Researchers wanted to see i…

This study tested a shorter, more intense 3-week radiation schedule combined with chemotherapy for people with a specific type of throat cancer linked to HPV. The goal was to see if this faster approach was safe and could control the cancer as well as the standard 7-week treatmen…

This study tested whether two long-acting, injectable medications—naltrexone and buprenorphine—could help people with cocaine use disorder reduce or stop their cocaine use. Over 400 adults participated in the 8-week trial, where half received the active medication injections and …

This study tested whether ketamine, a medication that can work quickly in adults, could reduce repeat suicidal events in teenagers. It involved 50 teens (ages 13-18) who had recently attempted suicide or had severe suicidal thoughts. Participants received either ketamine or a sed…

This small, completed study tested whether a specific type of laser (1927nm) could safely and effectively reduce dark spots (hyperpigmentation) on the face of people with darker skin tones (Fitzpatrick types V and VI). It also explored skincare routines to use before and after th…

This study tested if pregnenolone, a natural hormone sold as a supplement, could help reduce depression in women during or after menopause. Researchers compared pregnenolone to a placebo pill in 73 women to see if it improved mood, anxiety, hot flashes, and thinking skills. The g…

This study tested a new phone-based therapy program designed to help people with depression become more physically active. 65 adults with moderate to severe depression who exercised very little received 10 therapy sessions by phone or video. Researchers wanted to see if this appr…

This study tested whether adding a second nerve block (targeting the armpit area) to the standard nerve block for shoulder replacement surgery would improve pain control. Researchers measured if this combination reduced recovery room time, lowered opioid pain medication needs, an…

This study tested a combination of light-based laser treatments to improve the appearance of sun spots, skin texture, pores, and redness. Up to 15 participants received one or two treatments, and their skin was analyzed with special imaging before treatment and again at 1 and 3 m…

This study tested whether a gentle, non-invasive form of brain stimulation could improve memory in older adults. It focused on people with mild memory problems (amnestic mild cognitive impairment) who also had a past traumatic brain injury. Participants received 10 sessions of st…

This study tested a special movie system called PROMISE to help children with cancer stay still during radiation therapy without needing general anesthesia. The system plays a movie but pauses it if the child moves too much, encouraging them to hold still. Researchers hoped this …

This study tested whether giving two medications (fentanyl for pain/sedation and atropine) before a common breathing treatment for premature babies makes the procedure safer. It involved 58 infants born at 29 weeks or later who had respiratory distress. Researchers compared babie…

This small, completed study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could help adults whose concussion symptoms like headaches and dizziness lasted more than three months. Researchers compared the real oxygen treatment to a sham (…

This study tested whether giving higher doses of Vitamin D helps adults recover from serious burns. Researchers compared a standard daily dose (400 IU) against a much higher dose (4,000 IU) in 48 burn survivors. They measured whether the higher dose improved physical function, me…

This study aimed to understand why some people are very good or very poor at removing cholesterol from their blood vessels, a process linked to heart disease risk. Researchers studied 86 people from a Dallas-based study and their family members who had these extreme abilities. Th…

This study aimed to find new markers in the blood that could help predict how well standard liver cancer treatments work. Researchers took blood samples from 17 patients before and after they received their normal treatments, like TACE or ablation. The goal was to see if certain …

This study compared two common drugs used to support blood pressure during spinal fusion surgery. Researchers randomly assigned 101 patients to receive either norepinephrine or phenylephrine during their operation. The goal was to see if one drug leads to better recovery, includi…

This study looked at how common blood pressure medications affect blood flow to the brain and thinking skills in older adults. Researchers gave 27 older adults with high blood pressure either a real medication or a placebo for 1-2 weeks. They measured brain blood flow, nerve acti…

This study aimed to gather feedback from Black individuals to create a practical guidebook for researchers. The goal is to improve how clinical trials for substance use disorders recruit and keep Black participants, who are often underrepresented. The researchers worked with 65 p…

This study looked at whether improving a caregiver's depression could lead to better asthma control for their child. Researchers followed 205 caregiver-child pairs for one year, measuring depression and asthma symptoms regularly. The goal was to understand the connection between …

This study aimed to understand how natural changes in female sex hormones (like estrogen and progesterone) and birth control pills affect basic muscle and nerve function. Researchers measured reflexes, brain signals, and muscle responses in 102 healthy men and women to see if hor…

This study aimed to create a standard training program for doctors who place breathing tubes in critically ill patients. International experts used a structured survey method to agree on the essential skills and knowledge needed. The goal is to improve patient safety and reduce c…

This study aimed to understand if the body's immune system and inflammation are linked to suicidal thoughts and behaviors in teenagers. Researchers followed 225 teens, including some with recent suicidal behavior, some at risk for depression, and healthy teens, over 12 months. Th…

This study investigated how short-term steroid medication affects specific memory areas in the brain. Researchers gave healthy volunteers and some people with depression either hydrocortisone (a steroid) or a placebo for three days. They used detailed brain scans and memory tests…

This study created a registry to track how doctors use a precise form of radiation therapy (SBRT) in real-world cancer care. It followed 149 patients with advanced solid tumors to see how SBRT was used in four different situations, like treating a few remaining tumors or re-treat…

This small study tested whether using heat (radiofrequency ablation) could destroy adenomyosis tissue. Fifteen women who were already scheduled to have their uterus removed received the heat treatment just before their surgery. Researchers then examined the removed tissue under a…

This study aimed to understand the real-life experiences of children and young adults with blood disorders like clotting problems or bleeding conditions. Researchers interviewed 15 participants aged 12-21 about how their condition affects their daily life, emotions, and future pl…

This study tested a new way to encourage family members to get genetic testing for hereditary cancer risk. Researchers compared mailing home testing kits directly to relatives against the usual method of counseling the original patient. They measured how many relatives completed …

This study investigated how heat waves affect older adults' hearts compared to younger people. Researchers exposed 59 healthy participants to simulated heat wave conditions to measure heart stress and body temperature changes. The goal was to better understand why elderly people …