Could a 3-Week radiation blast tame HPV throat cancer?
NCT ID NCT04580446
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested a shorter, more intense radiation schedule (completed in 3 weeks instead of the usual 6) combined with chemotherapy for people with HPV-related throat cancer. The goal was to find the safest dose that still controls the cancer. Only 24 patients took part, and the main focus was on side effects, not yet on cure rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hypofractionated radiation therapy with weekly cisplatin
What this could lead to
If successful, this could lead to a shorter, more convenient radiation treatment for HPV-related throat cancer with fewer side effects.
What could go wrong
This is a very early phase 1 trial with only 24 people, so safety and effectiveness are not yet proven. The shorter radiation schedule might not control the cancer as well or could cause unexpected side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States