Could a 3-Week radiation blast tame HPV throat cancer?
NCT ID NCT04580446
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested a shorter, more intense radiation schedule (completed in 3 weeks instead of the usual 6) combined with chemotherapy for people with HPV-related throat cancer. The goal was to find the safest dose that still controls the cancer. Only 24 patients took part, and the main focus was on side effects, not yet on cure rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hypofractionated radiation therapy with weekly cisplatin
- What this could lead to
- If successful, this could lead to a shorter, more convenient radiation treatment for HPV-related throat cancer with fewer side effects.
- What could go wrong
- This is a very early phase 1 trial with only 24 people, so safety and effectiveness are not yet proven. The shorter radiation schedule might not control the cancer as well or could cause unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New hope for throat cancer patients: smarter treatments on the horizon