University Of Texas Southwestern Medical Center

This phase 2 trial is testing a combination of three drugs—ATRA (a vitamin A derivative), bevacizumab (a blood vessel growth blocker), and atezolizumab (an immunotherapy)—in 22 people with advanced colorectal cancer that has not responded to prior treatments. The goal is to see i…

This study tests whether combining two drugs, domvanalimab and zimberelimab, can shrink or control advanced liver and bile duct cancers that have stopped responding to earlier treatments. About 58 adults with these cancers will receive the drug combination. The main goal is to se…

This study tests whether the drug tafamidis can safely stop the progression of ATTR amyloidosis in people who have already received a heart transplant. About 25 stable patients will take tafamidis daily for 12 months. Researchers will measure changes in blood protein levels, nerv…

This study tests whether a special form of calcium and magnesium (effervescent calcium-magnesium citrate) can slow down harmful calcium buildup in the heart and blood vessels of people with end-stage kidney disease on dialysis. About 269 adults will take either this supplement or…

This study compares a new implant with special nanoLOCK technology to standard implants used in neck fusion surgery. The goal is to see if the new implant helps bones heal better and causes fewer swallowing problems. About 200 adults with neck pain or nerve issues will be randoml…

This study tests a shorter, more intense course of radiation therapy (hypofractionated IMRT) given after surgery for head and neck cancer. The goal is to see if it is safe and if it can help patients maintain better swallowing function compared to the standard longer radiation sc…

This study tests whether giving higher doses of focused radiation (stereotactic radiosurgery) to brain tumors is safe and effective, without also radiating the whole brain. About 135 adults with certain types of cancer that have spread to the brain will receive escalating radiati…

This phase 2 trial is testing whether combining immunotherapy drugs (pembrolizumab, ipilimumab, nivolumab) with a freezing technique called cryoablation before standard surgery can improve outcomes for women with triple-negative breast cancer. The study enrolls 51 women who have …

This phase 1 trial is testing a precise, high-dose radiation technique called SABR for men with high-risk prostate cancer. The goal is to find the highest safe dose to the prostate and pelvic lymph nodes while monitoring side effects. Sixty participants will receive five radiatio…

This study tests giving focused radiation to a tumor clot in the main vein before surgery for kidney cancer. The goal is to see if this approach is safe and helps prevent the cancer from coming back within a year. About 25 people with newly diagnosed kidney cancer and a clot in t…

This study tests whether semaglutide, a once-weekly injection, can improve blood sugar control in people with type 2 diabetes who are on chronic dialysis. About 43 participants will receive either semaglutide or a placebo for over a year, and their blood sugar levels will be trac…

This study tests a precise, non-invasive radiation treatment called SABR for people with small kidney tumors that are growing. The goal is to stop tumor growth without surgery. Sixteen adults with tumors 5 cm or smaller are participating.

This study tests an automated tool that uses patient risk levels to remind people with inflammatory bowel disease (IBD) when they need follow-up appointments. Researchers will compare how often patients are overdue for visits and whether this leads to fewer emergency room trips o…

This study looks at whether switching from natalizumab to cladribine tablets is safe and effective for people with relapsing forms of multiple sclerosis. About 40 adults aged 18-60 will take cladribine after stopping natalizumab. Researchers will track immune cell changes, relaps…

This phase 2 trial tests combining osimertinib, a daily targeted pill, with stereotactic ablative radiation (SABR), a precise high-dose radiation, in 41 people with advanced EGFR-mutant non-small cell lung cancer. The goal is to see if this combination improves how long the cance…

This study tested whether combining two drugs, afatinib and prednisone, can help people with advanced squamous non-small cell lung cancer who have already tried other treatments. The goal was to see if the combination could slow cancer growth. The trial enrolled 12 adults and mea…

This study tests a precise, 5-session radiation treatment called stereotactic partial breast irradiation (S-PBI) using a special device (GammaPod) for women with early-stage breast cancer. The goal is to see if this approach keeps the breast looking good (cosmesis) while controll…

This early-phase trial is testing whether a single, high dose of radiation given before surgery can safely treat early-stage breast cancer. Researchers are enrolling 45 women with small tumors (3 cm or less) to find the highest dose that does not cause severe side effects. If suc…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This study tests whether sending personalized screening invitations based on a person's race, ethnicity, and diabetes risk, plus offering phone navigation for those who don't respond, leads to more people getting tested for diabetes compared to generic invitations or usual care. …

This phase 2 trial is testing whether a special type of radiation therapy (SAbR) that avoids the nerves involved in erections can help preserve sexual function in men with localized prostate cancer. About 124 men will be randomly assigned to receive standard SAbR or a version tha…

This study tested a program to help bladder cancer patients recover better after bladder removal surgery. The program included extra monitoring and support before, during, and after the operation to catch problems early. The goal was to reduce complications within 90 days after s…

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

This early-stage study tests whether a novel light therapy, designed to reset the body's internal clock, is safe and can reduce fatigue in people with progressive multiple sclerosis. Twenty participants will receive the light therapy while researchers monitor side effects and mea…

This study tests whether adding methadone to usual morphine-based pain medicine reduces severe mouth pain in children aged 6–18 who are getting a stem cell transplant for leukemia, aplastic anemia, or similar conditions. The mouth pain is a common side effect of the chemotherapy …

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

This study is creating a collection of blood samples and health information from 250 adults with very high or very low cholesterol or related lipid problems. Researchers will analyze these samples to learn more about the genetic and biological causes of these extreme lipid disord…

This study looks at why some children and teens feel short of breath or have trouble exercising after their first blood clot in the leg (deep vein thrombosis) or lung (pulmonary embolism). Researchers will measure exercise capacity and breathing using special tests. The goal is t…

This study looks at how precise radiation (stereotactic radiosurgery) affects memory and thinking in people with 6 or more brain tumors that have spread from other cancers. About 80 adults will take part to find the safest radiation dose and measure any decline in memory over 4 m…

This study looks at how bone contributes to citrate levels in urine, which may help explain why some people have low urine citrate. Researchers will study 25 adults with untreated osteoporosis, giving them potassium citrate and measuring changes in urine citrate and bone markers.…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study follows 100 teens aged 13-18 who are already enrolled in a depression registry. For 30 days, they report their feelings and social media use twice daily via a phone app, then complete monthly surveys for 6 months. The goal is to understand how social media relates to d…

This study looks at how alcohol triggers the liver to create new fat, especially in women. Healthy volunteers drink a small amount of vodka and heavy water, then give blood samples to track fat production. Researchers want to see if adding sugar to alcohol increases this effect. …

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study follows 9 people with transverse myelitis who previously received an experimental cell therapy called Q-Cells®. Researchers will monitor them for 10 years to check for side effects and see if the treatment continues to have any effect. Participants will have regular ex…

This study reviews medical records of 10,000 people with lung or gastrointestinal cancers to see if PET scans can identify tumors that cause cachexia—a condition of severe weight loss and weakness. Researchers will compare PET scan results with patients' weight and performance st…

This study looks back at the medical records of 20,000 patients with lung or gastrointestinal cancer who also have cachexia (severe weight loss and muscle wasting). The goal is to learn how cachexia is currently managed and what factors affect patient outcomes. No treatments or t…

This study looks at how older adults with major depression handle emotions and make choices compared to healthy adults. Researchers will use brain scans and computer tasks to measure emotional recognition, reward processing, and impulsivity. The goal is to better understand the b…

This study aimed to compare two standard treatments for severe hemophilia A in children: extended half-life factor VIII and non-factor VIII therapies. Researchers planned to measure how well each treatment prevented bleeding and protected joint health using ultrasound. However, t…

This observational study follows 95 people with heart failure and preserved ejection fraction who are already receiving weight loss treatment as part of their standard care. Researchers will measure muscle blood flow, fat content, and inflammation before and after at least 7% wei…

This study looks at whether healthcare providers can use skills learned on mannequins when helping real newborns breathe. About 120 respiratory therapists will be observed in both a simulation lab and the delivery room. The goal is to see if their ability to manage a baby's mask …

This study records brain activity from 125 Parkinson's patients during deep brain stimulation (DBS) surgery. Participants perform tasks that involve making decisions, stopping actions, or switching between actions. The goal is to understand how brain circuits control movement and…

This study looks at whether using a Pedi-Cap, a device that changes color to show carbon dioxide levels, can shorten the time newborns need breathing help in the delivery room. About 632 infants born at 30 weeks or later who need face mask ventilation will be included. The resear…

This study follows 852 adults with liver cirrhosis who are scheduled for a TIPS procedure, a shunt placed in the liver to relieve dangerous high blood pressure. Researchers will collect information from standard medical care over 5 years to learn how to best use TIPS and reduce c…

This study follows 150 people with rare neuroimmunologic disorders like neuromyelitis optica and transverse myelitis. Researchers collect medical data and blood samples over time to learn what causes inflammation and why some patients respond to treatments while others do not. Th…

Short bowel syndrome is a rare condition where the bowel is too short to absorb enough nutrients. This study gives green bean puree to 60 adults with and without the condition to see if they can tolerate fiber. Researchers will track symptoms, weight, and changes in gut bacteria …

This study follows up on children who were first tested between ages 8-12, some with obesity and some without, to see how their lungs and exercise tolerance have changed after about 6 years. Researchers will measure lung volumes, oxygen use during exercise, and breathlessness. Th…