University Of Texas Southwestern Medical Center

This early-phase trial explores whether PSMA PET scans can help doctors adjust radiation therapy for men with prostate cancer that has spread to 4 to 20 spots in the body. Participants receive standard hormone therapy plus a special PET scan, then targeted radiation to all visibl…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This early-phase trial tests whether a new CAR T cell therapy called CC-97540 is safe for people with a rare autoimmune disease called neuromyelitis optica (NMOSD). The study will enroll 5 adults who are stable on current treatments. Researchers will check for side effects and wh…

This study tests whether people hospitalized for acute heart failure can be discharged early and continue treatment at home using a subcutaneous injection of furosemide (a diuretic) instead of staying in the hospital for standard IV diuretics. About 250 adults will be randomly as…

This study tests whether adding deucravacitinib to standard therapy helps adults with psoriatic arthritis that is not well controlled. About 128 participants will receive the combination and be monitored for 48 weeks. The goal is to reduce skin and joint symptoms and improve qual…

This study tests whether giving two drugs (ateganosine and cadonilimab) before surgery can safely shrink liver tumors in people with resectable hepatocellular carcinoma. About 60 participants will receive either one or both drugs before their operation. The main goal is to see if…

This study will test three different forms of potassium citrate—a medication that helps prevent kidney stones by making urine less acidic. Twenty adults who have had kidney stones will take each form for one week, with a week off in between. Researchers will measure changes in ur…

This study aims to see if a new radioactive dye can detect early signs of a heart condition called amyloidosis in people who carry a TTR gene mutation but have no heart failure symptoms. About 80 adults aged 30-80 will receive an injection of the dye and then have a PET/CT scan t…

This phase II trial tests whether a low dose of the cancer drug erlotinib can prevent liver cancer in 60 adults with advanced liver fibrosis or cirrhosis. Participants will take either erlotinib or a placebo daily for a set period. The study will measure changes in a blood protei…

This phase 2 trial tests whether potassium magnesium citrate, a supplement that provides key nutrients from the DASH diet, can lower blood pressure in African Americans with pre- or stage 1 hypertension. The study will enroll 45 participants and measure blood pressure over 24 hou…

This study tests if giving a long-lasting numbing medicine in two different places around the ribs and chest wall can reduce pain and the need for strong painkillers after robotic lung surgery. About 300 adults having this surgery will be randomly assigned to receive the numbing …

This study tests whether wearing compression garments on the legs can increase the amount of blood the heart pumps during exercise in adults with Fontan circulation. Twenty participants will undergo exercise tests with and without the garments, and a subset will wear them for two…

This study tests whether a device called Lymphatic Enhancement Technology (LET) can reduce pain and improve quality of life in women with fibromyalgia. Forty participants will receive either active or sham LET treatments once a week for four weeks. Researchers will measure change…

This study compares two methods of giving surfactant, a medicine that helps premature babies breathe. One method uses a thin tube, the other uses a small airway device. The goal is to see which method causes fewer breathing problems and complications in infants born at 29 weeks o…

This study tests two types of brain stimulation for people with depression that hasn't improved with medication. About 247 adults will receive either a precise, guided form of stimulation, a standard form, or a fake (sham) procedure. The goal is to see if these treatments can saf…

This study looks at how the brain works in 200 children with hard-to-treat epilepsy who are already scheduled for brain monitoring. Researchers will measure brain activity during tasks like learning and decision-making. The goal is to better understand thinking and memory, which …

This study looks at how data from an Operating Room Black Box can be used to create virtual training that helps surgical teams work better and safer. About 30 experienced operating room staff will test the simulator. The goal is to improve teamwork and safety checklists during re…

This study watches brain activity in 300 adults during high-risk surgeries like heart or spine operations. Researchers use special monitors to track brain waves and pressure, linking them to patient outcomes. The goal is to understand why some people develop confusion or brain in…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study looks at 300 adults with a brain bleed from a ruptured aneurysm. It tests a non-invasive headband to monitor brain blood flow and two nerve treatments (a neck injection and ear stimulation) to see if they improve brain function. The goal is to find better ways to preve…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study tests whether showing real-time visual feedback to EMS responders helps them deliver the right amount of air during simulated CPR. 80 rescuers will give breaths to a mannequin with and without feedback, using two different CPR strategies. The goal is to see if feedback…

This study tests whether a pop-up alert in electronic medical records can help primary care doctors order screening for HIV, hepatitis B, and hepatitis C all at once. About 50 primary care providers will participate, and their patient visits will be randomly assigned to either se…

This study tests whether sending automated messages to cancer patients after they leave the hospital can help them use urgent oncology care instead of the emergency room. About 200 patients will receive reminders via MyChart and text in English or Spanish. Researchers will track …

This early-phase study tests whether the drug Cobenfy KarXT can change brain activity linked to memory in 50 adults with epilepsy who are already scheduled for brain surgery. Participants will take either the drug or a placebo on separate days and perform memory tasks while their…

This early study tests whether applying low-intensity electric fields (TTFields) to the chest before lung cancer surgery is safe and affects cancer-related genes. About 18 adults with stage I-IIIA non-small cell lung cancer will wear a non-invasive device for a short time before …

This study compares over-the-counter and prescription alkalinizing agents to see how well they change urine chemistry and reduce kidney stone risk. Fifteen adults with or without a history of stones will follow a strict diet and take different medications. The goal is to find eff…

This study tests a training program where pediatricians practice talking about contraception with computer-generated avatars of a teen and her mother. The goal is to see if this boosts doctors' confidence and skills in shared decision-making. The study will enroll 166 medical res…