University Of Texas Southwestern Medical Center

This early-stage study is testing whether two drugs, ateganosine and cadonilimab, can help shrink liver tumors before surgery. The goal is to see if this approach makes the subsequent surgical removal more effective and is safe for patients. Participants will be randomly assigned…

This study is testing two newer forms of magnetic brain stimulation to see if they can help people with depression that hasn't gotten better with standard medications or therapy. Researchers will compare a more precise, guided method against a standard method and a placebo treatm…

This study is testing if it's safe and effective to send patients hospitalized for worsening heart failure home early. Instead of staying in the hospital for several days to receive standard IV diuretics, participants would go home and self-administer a similar medication as a si…

This study is testing a new, automated device for draining spinal fluid in older adults suspected of having a brain condition called normal pressure hydrocephalus (NPH). The device aims to make the drainage process safer, reduce nursing workload, and allow patients more freedom t…

This study aims to compare different forms of potassium citrate medication to see which works best for preventing kidney stones. Researchers will test three different versions (including prescription and over-the-counter options) with 20 adults who have had kidney stones before. …

This study is testing an existing program that teaches families of children with overweight or obesity about healthy eating and physical activity. About 160 children, aged 6-14, will be randomly assigned to start the program right away or wait three months. Researchers will measu…

This study will compare two different ways doctors can see what they're doing when giving a special lung medicine to very premature babies who are struggling to breathe. One method uses a video camera on the tool, while the other uses direct vision. Researchers want to see which …

This study aims to find cheaper, effective alternatives to an expensive prescription drug used to prevent kidney stones. Researchers will compare how different over-the-counter and prescription medications change the chemicals in urine that lead to stone formation. The study invo…

This study aims to find the best long-term approach for women who suffer from frequent bladder infections (cystitis). It will compare taking a daily antibiotic pill (nitrofurantoin) for six months against having a minor in-office bladder procedure (electrofulguration) followed by…

This study is testing two different methods for giving surfactant, a medicine that helps premature babies' lungs work better. Researchers will compare giving the medicine through a thin tube (LISA method) versus through a small airway device placed in the throat (SALSA method). T…

This study is testing whether adding a medication called deucravacitinib to a patient's current psoriatic arthritis treatment helps control symptoms better. It will enroll 128 adults whose arthritis isn't well-controlled despite their current therapy. The goal is to see if this t…

This study aims to find the most effective laser treatment for port-wine birthmarks in children and teenagers. Researchers will test five different laser methods on up to 200 participants to see which one works best to clear the birthmark color. The goal is to reduce the total nu…

This study is testing a mobile phone app called DynamiCare to see if it can help people recently released from jail or prison. The app provides rewards for staying drug-free and connects users with a personal guide to help them start HIV prevention or treatment medications. The g…

This study is testing if a simple computer alert can help doctors screen more patients for HIV, hepatitis B, and hepatitis C. When a doctor orders a test for one of these viruses, the alert will suggest adding tests for all three. The goal is to find more infections earlier by ma…

This study is testing whether a low dose of the cancer drug erlotinib can prevent liver cancer from developing in people who have advanced liver scarring (cirrhosis). Sixty participants will be randomly assigned to receive either the drug or a placebo for one year. Researchers wi…

This study is testing if a powder containing potassium, magnesium, and citrate, mixed into water, can help lower blood pressure in African American adults with early-stage or borderline high blood pressure. Researchers want to see if this supplement can mimic the benefits of a sp…

This study tests a new program to help prevent HIV by starting preventive medication right in the emergency room. A navigator will help 250 people in Dallas who are at risk for HIV get a prescription and a clinic appointment before they leave the ER. The goal is to see if this im…

This study is testing if text message reminders can help parents keep their teens safe after a visit to the emergency room for suicidal thoughts or actions. Researchers will enroll 129 families and randomly assign them to receive different types of text reminders or just usual ca…

This study is testing whether a device called Lymphatic Enhancement Technology (LET) can help people with fibromyalgia. Forty participants will receive four weekly treatments with either the real device or a look-alike sham device that doesn't work. Researchers will measure chang…

This study aims to find the best way to deliver long-acting numbing medication to control pain after robotic chest surgery for lung cancer. Researchers will compare three different nerve block locations to see which one best reduces pain and opioid medication use. The study will …

This early-stage study aims to understand how an experimental drug called Cobenfy KarXT affects brain activity related to memory. Researchers will test 50 adults with epilepsy who are already in the hospital having brain monitoring for their seizures. Each participant will take t…

This study aims to understand how the brain learns, remembers, and makes decisions by recording electrical activity in children with severe, medication-resistant epilepsy. Researchers will work with 200 children who are already undergoing brain monitoring as part of their standar…

This study aims to understand if showing real-time visual feedback helps emergency medical service (EMS) responders deliver better rescue breaths during CPR practice. Researchers will compare 80 EMS professionals performing CPR on a mannequin with and without feedback, using two …

This study aims to learn more about a new, non-invasive device that measures pressure inside the skull. Currently, measuring this pressure requires drilling a small hole in the skull. Researchers will test the new device, which uses a tiny pin on the head, on 30 adult patients wh…

This study aims to improve how doctors talk to teens and their parents about birth control. Researchers will create a virtual training program where doctors practice conversations with simulated teen and parent characters. They will test if this one-time training boosts doctors' …

This early research study aims to understand how Acetadote affects metabolism in glioblastoma brain tumors. Researchers will give Acetadote to 10 newly diagnosed patients before surgery, then analyze tumor tissue and MRI scans to see how the drug changes tumor chemistry. The goal…

This study aims to see how a non-invasive treatment called Tumor Treating Fields (TTFields) affects lung cancer cells before surgery. TTFields uses low-intensity electrical fields. The study will enroll 18 patients with early-stage lung cancer to check the safety of the treatment…

This study aims to understand if wearing compression garments (like special socks or stockings) can help improve blood flow back to the heart during exercise for adults with Fontan circulation, a complex single-ventricle heart condition. Researchers will measure heart function in…

This study aims to better understand the link between social media use and mental health in teenagers who are depressed or have suicidal thoughts. It will follow 100 teens, aged 13-18, for six months. Researchers will use a smartphone app to track social media use and ask partici…

This study aims to understand the connections between a teen's heart rate patterns, their ability to manage emotions, and the quality of their relationship with a parent. Researchers will enroll 74 adolescents diagnosed with depression. Participants will wear a Fitbit at night fo…