University Of Texas Southwestern Medical Center

This study aimed to compare two standard treatments for people with large intermediate-stage liver cancer that cannot be surgically removed. One group would receive a combination of two immunotherapy drugs (atezolizumab and bevacizumab), while the other would receive local treatm…

This phase 2 study tested the drug durvalumab (Imfinzi) combined with two different schedules of stereotactic radiation for people with advanced non-small cell lung cancer. The goal was to see if the combination improved quality of life and controlled tumor growth. However, the t…

This study aimed to see if Hiprex (methenamine hippurate) could reduce recurrent urinary tract infections in women aged 50 to 85. Participants took Hiprex daily for a year, and researchers counted infections and antibiotic use. However, the trial was terminated early with only 14…

This study tested whether a wearable device and digital care plan from the American Heart Association could help people with systolic heart failure. Participants wore the device for 90 days while their care team monitored their data. The trial was terminated early and only enroll…

This early-phase study tested a drug called abiraterone acetate (normally used for prostate cancer) in 4 children with congenital adrenal hyperplasia (CAH). The goal was to see if it could lower high male hormone levels and reduce the need for strong steroid medications that can …

This study looked at whether medically tailored meals and a behavioral app (Noom) could help people maintain weight loss after stopping GLP-1 medications like Wegovy. It enrolled 39 adults who had lost at least 10% of their body weight on GLP-1s and had stopped the drug within th…

This study looked at how anesthesia changes brain activity in people with Parkinson's disease or essential tremor who were already scheduled for deep brain stimulation (DBS) surgery. Researchers recorded brain signals during a short period of anesthesia to understand which circui…

This early-phase study tested whether a special MRI technique could detect early signs of heart damage caused by radiation therapy in people with thoracic or left-sided breast cancer. The approach used an injected substance (hyperpolarized pyruvate) to measure changes in heart ce…

This study looked at whether a special type of MRI, called Arterial Spin Labeling, can measure blood flow changes in kidney cancer tumors as early as two weeks after starting treatment. The goal was to see if this could help doctors know sooner whether a treatment is working. The…

This study aimed to see if spraying water on the body could help older adults with COPD stay cool during heat waves. Researchers planned to measure body temperature and lung function in a climate chamber. However, only one person took part before the study was stopped, so no mean…