Short course of letrozole before surgery may reveal breast Cancer's hormone dependence
NCT ID NCT03747042
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 2 trial enrolled 61 postmenopausal women with operable, hormone-sensitive breast cancer. Participants took letrozole for 7 to 30 days before their scheduled surgery. The goal was to measure changes in a tumor marker called Ki67 to see which cancers are highly hormone-dependent. The study did not aim to treat the cancer directly but to gather information that could guide future treatment decisions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
letrozole
What this could lead to
If successful, this could help doctors identify which breast cancers are highly hormone-dependent and may respond best to letrozole treatment.
What could go wrong
This is a small, early-phase study with only 61 participants, and it measures a biomarker (Ki67) rather than long-term outcomes like survival or recurrence.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, 75390, United States