Hidden heart risk: study aims to catch deadly protein buildup before symptoms start

NCT ID NCT05489549

Recruiting now Knowledge-focused Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is looking for early signs of heart amyloidosis in Black adults who carry a specific gene change (V122I TTR) that raises their risk. Researchers will use heart MRI scans and blood tests to detect protein buildup before symptoms appear. The goal is to find ways to diagnose the disease earlier, when treatments work best. About 500 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to earlier detection of heart amyloidosis in at-risk individuals, allowing treatment before heart failure develops.
What could go wrong: This is an observational study, not a treatment trial. It may not find reliable early markers, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Amyloid Neuropathies, Familial amyloidosis ATTRV122I amyloidosis familial amyloid neuropathy hereditary amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYLOIDOSIS CARDIAC AMYLOIDOSIS, FAMILIAL AMYLOIDOSIS, HEREDITARY TRANSTHYRETIN GENE MUTATION TRANSTHYRETIN-RELATED (ATTR) FAMILIAL AMYLOID CARDIOMYOPATHY

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

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