National Institute Of Allergy And Infectious Diseases (niaid)

This study tests a high-dose stem cell transplant to cure chronic granulomatous disease (CGD), a condition that weakens the immune system. About 45 people aged 4 to 65 with CGD will receive donor stem cells along with drugs to prevent rejection and graft-versus-host disease. The …

This early-phase study tests whether a bone marrow transplant from a partially matched relative can safely cure chronic granulomatous disease (CGD), a condition causing severe infections and inflammation. Up to 4 participants aged 4-65 will receive chemotherapy, radiation, and im…

This early-stage study tests two experimental HIV vaccines (UVAX-1107 and UVAX-1197) in 25 healthy adults without HIV. The main goals are to check if the vaccines are safe and to see how the immune system reacts. Participants will receive injections and have blood and lymph node …

This early-stage study tests two new vaccines designed to prevent HIV. Researchers want to see if they are safe and how the immune system reacts. The trial involves 45 healthy adults without HIV, aged 18 to 55, who will receive injections and be followed for about 16 months.

This early-stage study tests a new malaria vaccine made from genetically weakened malaria parasites. The goal is to see if it is safe and can train the immune system to fight malaria without causing the disease. Up to 22 healthy adults who have never had malaria will receive the …

This early-stage study tests whether an experimental vaccine can help people with HIV produce special antibodies called VRC01, which may fight the virus more effectively. About 35 participants will receive the vaccine and temporarily pause their regular HIV medication to see if t…

This early-stage trial tests a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, which is spread by mosquitoes. The study involves 30 healthy adults aged 18 to 49 who will receive either the vaccine or a placebo. Pa…

This early-stage study tests a new HIV vaccine in 36 healthy adults without HIV. The vaccine uses a two-step approach: first, a nanoparticle that displays HIV-like proteins, followed by an mRNA boost to strengthen the immune response. The goal is to see if this combination is saf…

This early-stage study tests three experimental mRNA vaccines designed to train the immune system against HIV. Researchers want to see if the vaccines are safe and whether they trigger the body to make antibodies that can neutralize the virus. The trial involves 108 healthy adult…

This early-stage study tests whether two experimental HIV vaccine priming regimens are safe and can activate special immune cells that make broad antibodies. 52 healthy adults without HIV will receive the vaccines, with some getting a booster shot later. The goal is to see if the…

This study tests whether giving infants an experimental antibody (L9LS) before a malaria vaccine is safe and helps the vaccine work better. About 180 babies in Mali, aged 1 to 12 months, will receive either L9LS or a placebo, then the R21/Matrix-M vaccine. Researchers will monito…

This study tests whether an experimental malaria vaccine (PfSPZ) is safe for pregnant women. Malaria can cause serious problems during pregnancy, including miscarriage and early delivery. The trial will involve 400 healthy pregnant women in Mali, some receiving the vaccine and ot…

This early-stage study tests a new mRNA vaccine designed to protect against bird flu (H5N1). About 80 healthy adults aged 18-49 will receive two doses of the vaccine. Researchers will closely monitor safety and measure the body's immune response over about 6 months.

This early-stage trial tests a new booster vaccine, STX-S, for COVID-19. About 60 healthy adults who have already received a primary vaccine series and at least one booster will get a single shot of STX-S at one of three dose levels. The main goal is to check safety and how well …

This early-stage study is testing a new mRNA-based flu vaccine in about 50 healthy adults aged 18 to 49. Participants will receive either the experimental vaccine at one of three dose levels or a licensed flu shot for comparison. The main goal is to see if the vaccine is safe and…

This early-stage study tests a new COVID-19 booster vaccine called PepGNP-COVID19 in 60 healthy adults aged 18-64. Unlike current vaccines, it uses tiny gold particles to train the body's T-cells to recognize and attack the virus, potentially providing broader and longer-lasting …

This early-stage study tests two experimental mRNA vaccines designed to teach the body to make powerful antibodies that can neutralize many strains of HIV. The trial involves 53 healthy adults without HIV to check safety and immune responses. If successful, this approach could le…

This study tests whether the HPV vaccine (Gardasil 9) can help people with a rare immune condition called ICL, who are more prone to severe HPV-related diseases. About 54 adults with ICL and some healthy volunteers will receive three vaccine doses over six months. Researchers wil…

This study looks at how a single dose of the medicine pretomanid works in children with rifampicin-resistant tuberculosis (a hard-to-treat form of TB). The goal is to understand how the drug moves through the body and whether it is safe and acceptable for children. About 32 child…

This study tests whether two drugs, daratumumab and belatacept, can lower immune sensitivity in kidney transplant candidates who are highly sensitized, meaning their bodies reject most donor kidneys. Nineteen participants with very high antibody levels receive the drugs to see if…

This study tests a new vaccine designed to help the immune system fight HIV in people who are already on successful HIV medication. About 30 adults with well-controlled HIV will receive either the vaccine or a placebo. The goal is to see if the vaccine is safe and can create new …

This study looked at three treatments for people with early HIV infection: zidovudine (AZT) alone, interferon alone, or both together. The goal was to see which worked best to lower the amount of virus in the blood, protect the immune system, and delay the first serious infection…

This study tests a new gene therapy for people with chronic granulomatous disease (CGD), a genetic disorder that makes them prone to severe infections. The treatment takes the patient's own stem cells, adds a missing gene in the lab, and puts them back into the body. The goal is …

This study tests whether the drug imatinib (Gleevec) can safely lower high levels of eosinophils (a type of white blood cell) in people with a rare condition called hypereosinophilic syndrome. About 70 participants with the myeloid form or those who didn't respond to steroids wil…

This study was designed to test a stem cell transplant for people with severe combined immune deficiency (SCID), a condition where the immune system doesn't work. The goal was to see if low-dose chemotherapy with or without radiation could help the body accept donor stem cells. H…

This early-phase study tests a new cell therapy in 9 liver transplant recipients. The goal is to see if giving patients their own specially trained immune cells (called Tregs) can allow them to safely stop or reduce their lifelong anti-rejection medications. The study focuses on …

This study tests a new gene therapy for X-linked severe combined immunodeficiency (X-SCID), a rare disorder that leaves people without a working immune system. Researchers take a person's own blood stem cells, fix the faulty gene using a precise editing technique called base edit…

This study tests whether two drugs, carfilzomib and belatacept, can lower the immune sensitivity of kidney transplant candidates who are highly sensitized—meaning their bodies reject most donor kidneys. The goal is to make it easier and quicker to find a compatible donor. About 2…

This study tests whether a combination of two drugs, dasatinib and quercetin (D+Q), can safely improve physical function in people aged 50 and older with HIV who are frail or prefrail. About 80 participants will receive either D+Q or a placebo over 12 weeks, then be monitored for…

This study tests whether the drug dupilumab can help prevent asthma attacks in children and teenagers aged 6 to 17 who live in urban areas and have frequent asthma problems. About 240 participants will receive either dupilumab or a placebo for one year, and researchers will count…

This study tested whether a long-acting injectable HIV medication works better than daily oral pills for people who have had trouble sticking to their treatment. 456 participants with HIV and a history of poor adherence were enrolled. The goal was to see if the injectable option …

This early-stage study tests whether two experimental antibodies (3BNC117-LS and 10-1074-LS) are safe and can reduce the hidden HIV reservoirs that persist even when standard antiretroviral therapy (ART) keeps the virus undetectable. About 105 adults with HIV who are stable on AR…

This study tests a gene transfer treatment for people with X-linked chronic granulomatous disease (X-CGD), a genetic condition that weakens the immune system and leads to severe infections. Researchers will take the participant's own stem cells, add a working copy of the faulty g…

This study tests two ways to prevent HIV: a rectal gel and oral pills, both taken only when needed. About 150 men will try each method for 8 weeks to see which is safer, easier to use, and preferred. The goal is to offer more choices for HIV prevention.

This study explores whether exposing C-section babies to their mother's vaginal bacteria shortly after birth can lower their risk of developing allergies and asthma. Researchers are enrolling 114 infants with a family history of allergic diseases. The goal is to see if this simpl…

This study tests whether the Bexsero meningitis vaccine can prevent gonorrhea, a sexually transmitted infection. About 2,600 adults aged 18-50 who are at higher risk for gonorrhea will receive either the vaccine or a placebo. Researchers will track how many get infected over 16 m…

This study compares a new long-acting injectable drug (cabotegravir) to daily oral pills for preventing HIV in women who are not infected. Over 3,200 women aged 18-45 took part. The goal is to see if the shot is safer and more effective at preventing HIV than the daily pill regim…

This study looks at the best way to protect babies from RSV, a serious lung infection. It compares giving a vaccine to pregnant women, giving a long-acting antibody to newborns, or using both. The goal is to see how well each approach works and how safe they are during the baby's…

This study looks at why some people without HIV or known immune problems still get serious infections like tuberculosis or fungal diseases. Researchers think a certain antibody in the blood might be the cause. About 224 adults in Thailand and Taiwan will be followed for 2 years t…

This study looks at whether a combination of two anti-HIV antibodies (bNAbs) can delay or lower the return of the virus after people stop their daily HIV medications. It involves 50 adults who previously received either the antibodies or a placebo in an earlier study. Participant…

This study follows 200 people who have recently had the flu to see how their immune system changes over two years. Researchers will take blood and nasal samples every three months to measure antibodies. The goal is to understand long-term immunity and help design more effective f…

This study aims to observe and follow people with inflammatory disorders, such as those caused by infections or immune system problems. Up to 500 participants aged 2 to 80 will receive standard medical care and tests. The main goal is to learn more about these conditions and iden…

This study looks at how having intestinal worms (helminths) and COVID-19 antibodies changes the immune system and gut bacteria. Researchers will collect blood and stool samples from 1500 people in India. The goal is to better understand these interactions, not to test a treatment…

This study aimed to see if the BCG vaccine could protect healthy adults from tuberculosis (TB) by measuring how the body fights the bacteria. It planned to enroll 64 people aged 18-45, giving some the vaccine and later a controlled exposure. However, the study was withdrawn befor…

This study aims to understand how the immune system reacts to a second infection with a mild bird flu strain (H10N7). Healthy adults who were infected with H10N7 in a previous study will be re-infected via a nasal spray and monitored in the hospital for at least 9 days. The goal …

This study takes small skin samples from people with immune system problems and healthy volunteers. The goal is to grow skin cells in the lab to study how the immune system works. These cells may one day help create personalized gene therapies for immune diseases. Participants mu…

This study follows 2,500 children from before birth up to age 3 (or 6 if they choose) to learn what causes food allergies and eczema. Researchers collect samples and track health to find early warning signs and biological pathways. The goal is to better understand these condition…

This study screens healthy adults aged 18-39 of African ancestry for alpha thalassemia trait, a common genetic deletion that can affect blood vessels. Participants provide a one-time saliva sample by mail or in person. The goal is to learn more about these deletions to help devel…

This study tracks how often people of all ages in two Liberian villages get malaria. Researchers will test blood monthly and check homes for mosquitoes. The goal is to gather data that could help use a future malaria vaccine more effectively. About 396 healthy residents aged 6 mo…

This study follows about 583 adults who have recovered from COVID-19 or were in close contact with someone infected. Researchers want to learn about any long-term medical problems that may appear after recovery and whether the body's immune response can prevent reinfection. Parti…

This study gives approved researchers access to blood samples and data collected from people who joined earlier HIV studies. The goal is to learn more about HIV and help create vaccines. All participants gave permission for their samples to be used in future research. The samples…

This study compares two tests for latent tuberculosis (a hidden TB infection) in 200 people with HIV in Liberia. Participants receive a skin test and a blood test to see which one works better. The goal is to find the best way to screen for TB in this high-risk group.

This study was designed to see if giving a lab-made antibody (L9LS) before a malaria vaccine (R21/Matrix-M) changes how well the vaccine works. It planned to enroll healthy adults and infants in Mali. However, the study was withdrawn before any participants were enrolled, so no r…

This study looks at whether the amount of HIV virus in people taking anti-HIV drugs for a long time stays the same or changes. It also checks if the virus develops new genetic changes while being suppressed. About 70 adults with HIV who have very low virus levels will join this 5…

This study aims to find out why some people have severe allergic reactions (anaphylaxis) without a clear cause. Researchers will look for genetic or molecular differences in immune cells (mast cells) from 115 participants aged 13 to 75. The study involves medical tests, blood wor…