National Institute Of Allergy And Infectious Diseases (niaid)

This study is testing a one-time gene therapy for people with X-linked Chronic Granulomatous Disease (X-CGD), a rare genetic disorder that cripples the immune system. Doctors will collect a patient's own blood stem cells, use a virus to insert a healthy copy of the faulty gene, a…

This study aimed to test a stem cell transplant procedure to cure Severe Combined Immune Deficiency (SCID), a life-threatening condition where the immune system doesn't work. Researchers wanted to see if using lower doses of chemotherapy drugs, with or without radiation, before t…

This early-phase study is testing whether a bone marrow transplant from a partially matched family member can cure chronic granulomatous disease (CGD), a rare immune disorder that causes severe infections. Researchers are using a special combination of medications and radiation b…

This study is testing a modified stem cell transplant procedure for people with chronic granulomatous disease (CGD), a rare genetic disorder where the immune system cannot fight certain infections. The goal is to cure the disease by replacing a patient's faulty immune cells with …

This early-phase trial is testing a new gene therapy for X-linked Severe Combined Immunodeficiency (X-SCID), a rare and life-threatening genetic disorder that severely weakens the immune system. Researchers will collect a participant's own blood stem cells, use a precise gene-edi…

This early-stage study is testing two new mRNA vaccines designed to protect against H5 avian influenza (bird flu) in healthy adults. Researchers will give 80 participants different doses to check for safety and see if the vaccines trigger an immune response. The study will help d…

This early-stage study is testing the safety and immune response of a new COVID-19 booster vaccine called PepGNP-COVID19. The vaccine uses tiny gold particles to deliver parts of the virus, aiming to train the body's T-cells for a strong and lasting defense, especially in the lun…

This early-stage study aimed to test the safety of the BCG tuberculosis vaccine in healthy adults. Researchers planned to give some participants the vaccine and then expose all participants to a weakened TB strain six months later to measure immune responses. The study was withdr…

This is an early-stage study to test the safety and immune response of a new mRNA flu vaccine in healthy adults. Up to 50 participants, aged 18-49, will receive two doses of the experimental vaccine or one dose of a standard flu shot for comparison. The main goal is to see if the…

This early-stage study is testing two experimental HIV vaccine regimens in 52 healthy adults without HIV. The main goals are to check if the vaccines are safe and to see if they can trigger the immune system to produce special antibodies that might protect against many strains of…

This study is testing a new vaccine designed to prevent severe diarrhea caused by a common bacteria (ETEC) often linked to traveler's diarrhea. About 72 healthy adults will receive either the vaccine or a placebo shot, then be intentionally exposed to the bacteria to see if the v…

This is an early-stage study to check the safety and immune response of a new experimental HIV vaccine in healthy adults who do not have HIV. Researchers will give the vaccine candidate, which uses a protein from the HIV virus combined with an immune-boosting particle, to 57 volu…

This early-stage clinical trial is testing a new vaccine designed to prevent infection with Epstein-Barr virus (EBV), which causes mononucleosis ('mono') and is linked to certain cancers. The study involves healthy young adults aged 18-25 who have never had EBV before. Participan…

This is an early-stage study to check the safety and immune response of three new experimental mRNA vaccines designed to prevent HIV. The study will enroll 108 healthy, HIV-negative adults to receive injections and be closely monitored for side effects. The main goal is to see if…

This is the first human study of two experimental HIV vaccines given in combination. Researchers want to see if the vaccines are safe and if they trigger a strong immune response in healthy volunteers without HIV. The study will enroll 25 participants who will be monitored for ab…

This is an early-stage safety study testing two experimental mRNA vaccines designed to train the immune system against HIV. The trial will enroll 53 healthy adults without HIV to check if the vaccines are safe and can trigger an immune response. This is a first-in-human study, me…

This is the first human trial testing two new experimental HIV vaccines. Researchers want to see if the vaccines are safe and if they trigger a helpful immune response in healthy volunteers. The study will follow 45 HIV-negative adults for about 16 months, checking for side effec…

This is a very early, first-in-human study to check if a new two-part HIV vaccine is safe and can trigger an immune response. It involves 36 healthy adults without HIV. Volunteers receive a shot of a nanoparticle-based vaccine followed later by a booster shot using mRNA technolog…

This is an early-stage study to check if a new experimental malaria vaccine is safe and can trigger an immune response. It will involve 22 healthy adults who have never had malaria. Researchers will give participants the vaccine or a placebo, then later expose them to malaria par…

This early-stage study is testing the safety and immune response of a new COVID-19 booster vaccine called STX-S. Researchers will give 60 healthy adults who are already fully vaccinated one of three different low doses to see how their bodies react. The main goal is to find a saf…

This is an early-stage safety study for a new vaccine designed to prevent West Nile virus infection, which is spread by mosquitoes. The main goal is to check if the vaccine is safe and if it triggers an immune response in 30 healthy adults aged 18-49. Participants will receive ei…

This study is testing a new gene therapy for people with a rare, inherited immune disorder called p47 chronic granulomatous disease (CGD). Doctors will collect a patient's own blood stem cells, add a corrected copy of the missing gene in a lab, and then return the modified cells …

This early-stage study is testing whether the drug tofacitinib is safe and can help control severe inflammation in adults with chronic granulomatous disease (CGD). CGD is a rare immune disorder where people get frequent infections and often develop painful inflammation in their g…

This study is testing a new oral medication called selgantolimod in people who have both chronic hepatitis B and HIV. The main goals are to see if the drug is safe and if it can lower the amount of hepatitis B surface antigen in the blood, which is a key marker of the infection. …

This study is testing if a combination of two lab-made antibodies can help the body control HIV for a longer time after people temporarily stop their regular antiretroviral therapy (ART). It involves 50 people with HIV who were in a previous study where some received these antibo…

This study is testing whether two existing drugs, daratumumab and belatacept, can help kidney transplant patients who are 'highly sensitized'—meaning their immune systems attack most donor kidneys. The treatment aims to lower these harmful antibodies, making it easier to find a c…

This early-stage study is testing a new therapeutic vaccine in adults who are living with HIV and have their virus well-controlled with daily medication. The main goals are to check if the vaccine is safe and to see if it can teach the body's immune system to better fight the vir…

This study is testing whether two new antibody drugs, given by IV infusion, are safe and can reduce the amount of hidden, dormant HIV that persists in the body even during effective treatment. It involves 105 adults with well-controlled HIV who are already on standard antiretrovi…

This study compares three different treatment approaches for people with early HIV infection: AZT alone, interferon alone, or both drugs combined. Researchers followed 180 participants for decades to see which approach best controls the virus, preserves immune function, and delay…

This study tested if monthly injections of HIV medication work better than daily pills for people who have a hard time taking their medicine regularly. It involved 456 adults with HIV who had a history of poor medication adherence. The trial was so successful that an independent …

This study is testing whether two drugs, carfilzomib and belatacept, can help people who have been waiting a very long time for a kidney transplant. These patients have immune systems that attack most donor kidneys, making it extremely hard to find a match. The goal is to see if …

This study is testing if adding a medication called dupilumab to standard asthma treatment can help prevent severe asthma attacks in children and teenagers living in urban areas. About 240 participants, aged 6 to 17, who have frequent asthma flare-ups will receive either the new …

This study is testing whether a drug called imatinib (Gleevec®), which is used for some cancers, can safely and effectively lower dangerously high levels of a specific white blood cell (eosinophils) in people with hypereosinophilic syndrome (HES). HES is a rare condition where to…

This study is testing a one-time antibody injection (L9LS) to see if it is safe for infants and if it interferes with a later malaria vaccine. It involves 180 healthy infants in Mali, aged 1 to 12 months. Researchers will give some infants the antibody and others a placebo, then …

This study is testing whether the Gardasil 9 HPV vaccine can help prevent HPV-related diseases in adults with a rare immune condition called Idiopathic CD4 T Cell Lymphocytopenia (ICL). People with ICL get more frequent and severe HPV infections. Researchers are giving the vaccin…

This study is testing if an existing meningitis vaccine called Bexsero can also prevent gonorrhea infections. It will involve about 2,200 adults aged 18-50 who are at higher risk for getting gonorrhea. Participants will receive either the vaccine or a placebo shot and be followed…

This study aims to test the safety of an experimental malaria vaccine (PfSPZ) in pregnant women. It involves 400 healthy pregnant participants in Mali who will receive either the vaccine or a placebo injection. Researchers will closely monitor the women and their babies for over …

This large study is testing if a long-acting injection given every two months works as well as a daily pill to prevent HIV infection in women. It enrolled over 3,200 women at risk for HIV to compare the safety and effectiveness of the two methods. The goal is to offer a more conv…

This early-stage study is testing the safety of a new antibody injection called CAP256J3LS in healthy adults. The antibody is designed to target and neutralize HIV, potentially preventing infection. Researchers are giving the antibody as either a single shot or three shots over s…

This study aims to find out which of two approved methods provides better and longer-lasting protection for babies against severe RSV, a common and dangerous respiratory virus. Researchers will compare giving a vaccine to pregnant mothers, giving a protective antibody shot to new…

This study is testing whether transferring vaginal bacteria to babies born by C-section can help prevent allergies and asthma. Researchers are comparing C-section babies who receive this transfer with those who don't, and with babies born vaginally. The goal is to see if this ear…

This study aims to compare two on-demand HIV prevention methods for men who have anal sex. Participants will try both a rectal douche and oral pills containing the drug tenofovir, in a random order, to see which is safer and more acceptable. The research will measure side effects…

This study is testing whether a combination of two drugs, dasatinib and quercetin, can improve physical function in older adults with HIV who are experiencing frailty or early signs of frailty. The trial involves 82 participants aged 50+ who have had HIV for at least 10 years and…

This study aims to understand how the body's immune response to the flu virus changes long after an infection. Researchers will follow 200 people who have recently had the flu, checking their blood and health every three months for two years. The goal is to learn how protective a…

This study aims to discover why some people experience severe, life-threatening allergic reactions called anaphylaxis, especially when no clear cause can be found. Researchers will examine patients aged 13-75 who have had these reactions to food, drugs, insect venom, or from unkn…

This early-stage study is testing a new HIV vaccine candidate in 35 people already living with well-controlled HIV. The main goal is to see if the vaccine can safely trigger the body to produce a specific type of antibody that might fight the virus. To measure this, participants …

This study aims to understand the long-term health problems people might have after recovering from COVID-19 and whether they develop lasting protection against getting it again. Researchers will follow 583 adults who either recovered from COVID-19 or were close contacts but didn…

This study collects small skin samples from people with immune system disorders and healthy volunteers to create cell lines for research. Researchers want to understand what causes these disorders and explore whether cells could be modified for future gene therapies. The study wi…

This study aims to find the most effective way to screen for hidden (latent) tuberculosis in people living with HIV in Liberia. Researchers are comparing two different skin tests to see which one works better in this setting. The study involves 200 adult participants who are alre…

This study aims to discover the earliest signs and biological causes of food allergies and eczema in children. Researchers will follow 2500 children from before birth until age 6, collecting samples and health information. The goal is to identify markers that predict which childr…

This study aims to understand what happens when people are exposed to the same mild bird flu virus a second time. Researchers will re-expose 33 healthy adults who caught this specific flu in a previous study. The goal is to learn if they get sick again and how their immune system…

This study aims to understand how a common genetic trait, called alpha thalassemia trait, affects blood vessels. Researchers are collecting saliva samples from healthy adults of African ancestry to identify people with this trait. The goal is to learn why this trait seems to prot…

This study aims to observe and follow people with various inflammatory conditions over time, not to test a new treatment. It will create a group of patients who might be eligible for future research studies and help train doctors. Participants will receive standard medical evalua…

This study aims to understand why some people who are not HIV-positive and have no known immune problems still get serious, hard-to-treat infections. Researchers will follow about 210 patients in Thailand and Taiwan who have these infections, giving them standard treatments and m…

This study aims to understand how common parasitic worm infections might affect people's immune response to COVID-19. Researchers will collect one-time blood and stool samples from 1,500 people in India to measure COVID-19 antibodies and check for worm infections. The goal is to …

This study allows approved researchers to continue analyzing blood samples and data collected during previous HIV vaccine trials. Participants had already consented for their samples to be used in future research when they joined the original studies. The goal is to learn more ab…

This early-stage study is testing a potential new dengue vaccine in healthy adults to see if it's safe and how people's immune systems respond differently based on whether they've had dengue before. Researchers are enrolling 127 participants aged 18-59 who have never had dengue, …

This study aims to gather detailed information about how often people in two Liberian villages get malaria over time. Researchers will follow about 400 residents of all ages for up to 3 years, checking them monthly for malaria infections and collecting mosquitoes from their homes…

This study aims to understand how HIV behaves in people who have been taking antiviral medications for many years. Researchers will follow 70 HIV-positive adults for at least 5 years to see if the virus level continues to decrease or stays stable, and whether new genetic changes …