Can two antibodies flush out hidden HIV? new trial aims to reduce lifelong pills

NCT ID NCT05612178

First seen Feb 01, 2026 · Last updated May 05, 2026 · Updated 21 times

Summary

This early-stage study tests whether two experimental antibodies (3BNC117-LS and 10-1074-LS) are safe and can reduce the hidden HIV reservoirs that persist even when standard antiretroviral therapy (ART) keeps the virus undetectable. About 105 adults with HIV who are stable on ART will receive three infusions of the antibodies or a placebo over 40 weeks. The goal is to see if these antibodies can lower the number of infected cells, potentially reducing the need for lifelong daily medication.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • The Rockefeller University

    New York, New York, 10065, United States

Conditions

Explore the condition pages connected to this study.