New hope for Drug-Resistant HIV: early access to TMC125

NCT ID NCT00354627

APPROVED_FOR_MARKETING Disease control Sponsor: Tibotec Pharmaceuticals, Ireland Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study provides early access to the experimental drug TMC125 (etravirine) for HIV-1 patients who have failed multiple treatments and have few options left. Participants take TMC125 along with other antiretroviral drugs chosen by their doctor. The study tracks safety and how well the drug works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

TMC125 (etravirine)

What this could lead to

If successful, this could provide a new treatment option for people with drug-resistant HIV who have run out of effective therapies.

What could go wrong

This is an early access program, not a controlled trial, so results may be less reliable. The drug may not work for everyone and could have side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1

Contacts and locations

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Locations

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Anniston, Alabama, United States
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Birmingham, Alabama, United States
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Flagstaff, Arizona, United States
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Phoenix, Arizona, United States
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Tucson, Arizona, United States
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Little Rock, Arkansas, United States
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Anaheim, California, United States
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Arcata, California, United States
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Bakersfield, California, United States
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Baldwin Park, California, United States
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Bellflower, California, United States
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Beverly Hills, California, United States
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Fontana, California, United States
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Fountain Valley, California, United States
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Fremont, California, United States
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Garden Grove, California, United States
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Glendale, California, United States
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Harbor City, California, United States
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Hayward, California, United States
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Loma Linda, California, United States
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Long Beach, California, United States
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Los Angeles, California, United States
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Newport Beach, California, United States
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Oakland, California, United States
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Palm Springs, California, United States
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Palo Alto, California, United States
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Panorama City, California, United States
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Pasadena, California, United States
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Pico Rivera, California, United States
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Richmond, California, United States
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Sacramento, California, United States
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San Bernardino, California, United States
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San Diego, California, United States
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San Francisco, California, United States
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San Mateo, California, United States
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San Rafael, California, United States
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Santa Ana, California, United States
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Santa Clara, California, United States
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Santa Clarita, California, United States
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Santa Rosa, California, United States
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Stanford, California, United States
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Tarzana, California, United States
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Ukiah, California, United States
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Ventura, California, United States
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Woodland Hills, California, United States
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Denver, Colorado, United States
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Wheat Ridge, Colorado, United States
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Glastonbury, Connecticut, United States
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Hartford, Connecticut, United States
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New Haven, Connecticut, United States
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Norwalk, Connecticut, United States
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Norwich, Connecticut, United States
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Washington D.C., District of Columbia, United States
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Daytona Beach, Florida, United States
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Fort Lauderdale, Florida, United States
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Hollywood, Florida, United States
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Jacksonville, Florida, United States
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LaBelle, Florida, United States
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Leesburg, Florida, United States
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Miami, Florida, United States
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Miami Beach, Florida, United States
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North Miami Beach, Florida, United States
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North Palm Beach, Florida, United States
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Oakland Park, Florida, United States
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Orlando, Florida, United States
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Pensacola, Florida, United States
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Plantation, Florida, United States
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Port Saint Lucie, Florida, United States
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Safety Harbor, Florida, United States
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Sarasota, Florida, United States
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Tampa, Florida, United States
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Tarpon Springs, Florida, United States
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Vero Beach, Florida, United States
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West Palm Beach, Florida, United States
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Weston, Florida, United States
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Winter Park, Florida, United States
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Atlanta, Georgia, United States
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Decatur, Georgia, United States
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Jesup, Georgia, United States
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Macon, Georgia, United States
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Riverdale, Georgia, United States
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Savannah, Georgia, United States
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Tucker, Georgia, United States
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Honolulu, Hawaii, United States
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Boise, Idaho, United States
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Aurora, Illinois, United States
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Chicago, Illinois, United States
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Joliet, Illinois, United States
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Maywood, Illinois, United States
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Indianapolis, Indiana, United States
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Des Moines, Iowa, United States
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Iowa City, Iowa, United States
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Henderson, Kentucky, United States
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Paducah, Kentucky, United States
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New Orleans, Louisiana, United States
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Ellsworth, Maine, United States
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Portland, Maine, United States
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Baltimore, Maryland, United States
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Greenbelt, Maryland, United States
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Silver Spring, Maryland, United States
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Boston, Massachusetts, United States
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Springfield, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Berkley, Michigan, United States
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Detroit, Michigan, United States
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Grand Rapids, Michigan, United States
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Grosse Pointe Woods, Michigan, United States
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Lansing, Michigan, United States
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Minneapolis, Minnesota, United States
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Rochester, Minnesota, United States
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Saint Louis Park, Minnesota, United States
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Kansas City, Missouri, United States
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St Louis, Missouri, United States
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Lincoln, Nebraska, United States
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Las Vegas, Nevada, United States
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Rochester, New Hampshire, United States
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Englewood, New Jersey, United States
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Hackensack, New Jersey, United States
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Long Branch, New Jersey, United States
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Neptune City, New Jersey, United States
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Newark, New Jersey, United States
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Perth Amboy, New Jersey, United States
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Somers Point, New Jersey, United States
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Union, New Jersey, United States
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Voorhees Township, New Jersey, United States
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Westfield, New Jersey, United States
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Santa Fe, New Mexico, United States
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Albany, New York, United States
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Briarcliff Manor, New York, United States
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Brooklyn, New York, United States
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Buffalo, New York, United States
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East Meadow, New York, United States
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Elmira, New York, United States
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Flushing, New York, United States
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Kingston, New York, United States
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Manhasset, New York, United States
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Mount Vernon, New York, United States
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New York, New York, United States
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Rochester, New York, United States
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Staten Island, New York, United States
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The Bronx, New York, United States
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Chapel Hill, North Carolina, United States
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Gastonia, North Carolina, United States
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Huntersville, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Akron, Ohio, United States
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Cleveland, Ohio, United States
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Columbus, Ohio, United States
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Dayton, Ohio, United States
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Portland, Oregon, United States
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Allentown, Pennsylvania, United States
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Johnstown, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Providence, Rhode Island, United States
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Charleston, South Carolina, United States
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Columbia, South Carolina, United States
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Johnson City, Tennessee, United States
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Nashville, Tennessee, United States
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Austin, Texas, United States
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Bellaire, Texas, United States
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Dallas, Texas, United States
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El Paso, Texas, United States
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Fort Worth, Texas, United States
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Harlingen, Texas, United States
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Houston, Texas, United States
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Longview, Texas, United States
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San Antonio, Texas, United States
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Annandale, Virginia, United States
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Charlottesville, Virginia, United States
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Fairfax, Virginia, United States
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Hampton, Virginia, United States
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Norfolk, Virginia, United States
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Richmond, Virginia, United States
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Olympia, Washington, United States
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Seattle, Washington, United States
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Spokane, Washington, United States
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Yakima, Washington, United States
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Charleston, West Virginia, United States
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La Crosse, Wisconsin, United States
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Madison, Wisconsin, United States
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Milwaukee, Wisconsin, United States
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Antwerp, Belgium
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Bruges, Belgium
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Brussels, Belgium
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Charleroi, Belgium
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Ghent, Belgium
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Leuven, Belgium
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Liège, Belgium
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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Vancouver, British Columbia, Canada
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Winnipeg, Manitoba, Canada
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Moncton, New Brunswick, Canada
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Hamilton, Ontario, Canada
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Kingston, Ontario, Canada
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London, Ontario, Canada
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Ottawa, Ontario, Canada
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Toronto, Ontario, Canada
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Whitby, Ontario, Canada
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Windsor, Ontario, Canada
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Montreal, Quebec, Canada
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Ste-Foy, Quebec, Canada
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Aarhus, Denmark
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Copenhagen, Denmark
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Hvidovre, Denmark
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Odense, Denmark
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Aachen, Germany
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Berlin, Germany
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Bochum, Germany
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Bonn, Germany
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Cologne, Germany
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Düsseldorf, Germany
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Erlangen, Germany
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Essen, Germany
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Frankfurt, Germany
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Freiburg im Breisgau, Germany
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Hamburg, Germany
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Hanover, Germany
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Koblenz, Germany
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Mainz, Germany
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Mannheim, Germany
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Munich, Germany
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München, Germany
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Münster, Germany
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Osnabrück, Germany
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Stuttgart, Germany
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Würzburg, Germany
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Athens, Greece
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Pátrai, Greece
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Thessalonikis, Greece
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Luxembourg, Luxembourg
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Bosques Del Nogalar San Nicola, Mexico
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Chihuahua City, Mexico
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Col Tacuba, Mexico
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Guadalajara, Mexico
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León, Mexico
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Mexico City, Mexico
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Monterrey Nuevo León, Mexico
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Oaxaca City, Mexico
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Puebla City, Mexico
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Tabasco, Mexico
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Tijuana, Mexico
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Veracruz, Mexico
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Alkmaar, Netherlands
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Amsterdam, Netherlands
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Amsterdam-Zuidoost, Netherlands
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Arnhem, Netherlands
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Eindhoven, Netherlands
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Groningen, Netherlands
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Leiden, Netherlands
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Maastricht, Netherlands
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Nijmegen, Netherlands
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Rotterdam, Netherlands
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The Hague, Netherlands
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Tilburg, Netherlands
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Utrecht, Netherlands
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San Juan, Puerto Rico
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Kazan', Russia
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Moscow, Russia
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Oryol, Russia
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Saint Petersburg, Russia
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Smolensk, Russia
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Volgograd, Russia
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Kyungki, South Korea
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Pusan, South Korea
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Seoul, South Korea
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A Coruña, Spain
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Alicante, Spain
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Barakaldo Vizcaya, Spain
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Barcelona, Spain
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Bilbao, Spain
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Cadiz, Spain
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Córdoba, Spain
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Cuenca, Spain
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Donostia Guipuzcoa, Spain
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Elche, Spain
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Granada, Spain
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Granollers, Spain
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Logroño, Spain
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Madrid, Spain
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Málaga, Spain
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Murcia, Spain
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Oviedo, Spain
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Palma de Mallorca, Spain
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Pamplona, Spain
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Sabadell, Spain
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San Cristóbal de La Laguna, Spain
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Santa Cruz de Tenerife, Spain
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Santiago de Compostela (La Cor, Spain
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Seville, Spain
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Terrassa, Spain
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Valencia, Spain
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Vigo, Spain
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Vitoria-Gasteiz, Spain
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Zaragoza, Spain
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Gothenburg, Sweden
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Malmö, Sweden
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Stockholm, Sweden
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Ankara, Turkey (Türkiye)