Partial match, full hope: new transplant approach aims to cure rare immune disease

This early-phase study tests whether a bone marrow transplant from a partially matched relative can safely cure chronic granulomatous disease (CGD), a condition causing severe infections and inflammation. Up to 4 participants aged 4-65 will receive chemotherapy, radiation, and immune-suppressing drugs before and after the transplant to help their bodies accept the new cells. The goal is to achieve long-term donor cell engraftment without severe graft-versus-host disease.