Could a Half-Matched donor cure a rare immune disease?
NCT ID NCT03910452
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether a bone marrow transplant from a partially matched relative can safely cure chronic granulomatous disease (CGD), a condition that causes severe infections and inflammation. Four people aged 4 to 65 with CGD and no perfect donor will receive chemotherapy, radiation, and immune-suppressing drugs before and after the transplant to help their body accept the new cells. The goal is to see if the transplant can restore normal immune function without causing severe graft-versus-host disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bone marrow transplant from a partially matched relative, with chemotherapy (busulfan), immune-suppressing drug (alemtuzumab), radiation, and post-transplant cyclophosphamide
What this could lead to
If it works, this could offer a cure for people with chronic granulomatous disease who don't have a perfectly matched donor.
What could go wrong
This is a very early, small trial (only 4 people) testing a high-risk procedure. The transplant may fail, cause severe graft-versus-host disease, or lead to serious infections or other complications.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States