HIV prevention breakthrough? monthly shot could replace daily pill for women

NCT ID NCT03164564

First seen Oct 31, 2025 · Last updated May 09, 2026 · Updated 24 times

Summary

This study compares a new long-acting injectable drug (cabotegravir) to daily oral pills for preventing HIV in women who are not infected. Over 3,200 women aged 18-45 took part. The goal is to see if the shot is safer and more effective at preventing HIV than the daily pill regimen.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Baylor-Uganda CRS

    Kampala, Uganda

  • Blantyre CRS

    Blantyre, Malawi

  • Botha's Hill CRS

    Durban, KwaZulu-Natal, 3660, South Africa

  • Desmond Tutu TB Centre - Stellenbosch University (DTTC-SU) CRS

    Cape Town, Western Cape, 7505, South Africa

  • Emavundleni CRS

    Cape Town, Western Cape, 7750, South Africa

  • Eswatini Prevention Center CRS

    Mbabane, Eswatini

  • Gaborone CRS

    Gaborone, South-East District, Botswana

  • Isipingo CRS

    Isipingo, KwaZulu-Natal, 4110, South Africa

  • Kisumu Crs

    Kisumu, Nyanza, 40100, Kenya

  • MU-JHU Research Collaboration (MUJHU CARE LTD) CRS

    Kampala, Uganda

  • Malawi CRS

    Lilongwe, Central Region, Malawi

  • Milton Park CRS

    Harare, Zimbabwe

  • Seke South CRS

    Chitungwiza, Zimbabwe

  • Soweto HPTN CRS

    Johannesburg, Gauteng, 1862, South Africa

  • Spilhaus CRS

    Harare, Zimbabwe

  • St Mary's CRS

    Chitungwiza, Zimbabwe

  • UVRI-IAVI HIV Vaccine Program LTD. CRS

    Entebbe, Uganda

  • Verulam CRS

    Verulam, KwaZulu-Natal, 4340, South Africa

  • Ward 21 CRS

    Johannesburg, Gauteng, 2001, South Africa

  • Zengeza CRS

    Chitungwiza, Mashonaland East Province, Zimbabwe

Conditions

Explore the condition pages connected to this study.