National Institute Of Allergy And Infectious Diseases (niaid)

This study is testing whether giving a single dose of an antibody called L9LS can improve how well the body responds to a new malaria vaccine, R21/Matrix-M. It will involve 24 healthy adults and 333 healthy infants in Mali. Researchers want to see if the timing of the antibody sh…

This is a first-in-human, early-stage trial to test the safety and immune response of two new experimental HIV vaccines. The vaccines, called DV201P-RNA and DV202B1-RNA, use mRNA technology (similar to some COVID-19 vaccines) to train the immune system to fight HIV. The study wil…

This study is testing an experimental flu vaccine called BPL-1357 to see if it is safe and can protect people from getting sick with the flu. Healthy adults aged 18-55 will receive the vaccine either as a shot in the arm, a spray in the nose, or a placebo. Later, some participant…

This early safety study is testing whether two lab-made antibodies can help control HIV when people temporarily stop their regular antiviral medication. It will involve 40 adults living with HIV who started treatment very soon after infection. Researchers want to see if the antib…

This study is testing whether adding two new drugs, carfilzomib and belatacept, to the standard anti-rejection medications can better control a specific type of kidney transplant rejection. It will involve about 25 kidney transplant patients whose bodies are making harmful antibo…

This study is testing whether alendronate, a medication commonly used for bone health, can reduce the hidden reservoir of HIV in people who are already on effective antiviral therapy. Thirty participants will be randomly assigned to receive either alendronate or a placebo pill, a…

This early-stage study is testing whether the cancer medication dasatinib can reduce the hidden HIV that persists in the body even during effective treatment. Fourteen adults with well-controlled HIV on long-term therapy will take either dasatinib or a placebo pill for 12 weeks. …

This large study aims to find out if giving a common steroid (prednisolone) for one week helps hospitalized adults with severe lung infections and low oxygen levels. It will compare the steroid treatment to no steroids to see which approach leads to better survival, shorter hospi…

This study is testing if a drug called tezepelumab can make a standard peanut allergy treatment more effective. It will involve 62 people aged 12-55 with a confirmed peanut allergy. The goal is to see if the drug helps people build a lasting tolerance to peanut protein, even afte…

This study aims to find out if a common hepatitis C medicine is safe and works properly when taken during pregnancy. It will enroll 30 pregnant women with hepatitis C, with or without HIV, to measure drug levels in their bodies and check for side effects in both mothers and their…

This study aims to find the safest and most effective dose of a 28-day medicine combination to prevent tuberculosis (TB) in children under 13 years old. It will include up to 144 children, both with and without HIV, who are at risk of getting TB. Researchers will closely monitor …

This early-stage study is testing the safety of three lab-made antibodies designed to prevent HIV infection. Researchers will give these antibodies, alone and in combination, to 83 healthy adults without HIV to check for side effects and see how the body processes them. The goal …

This study aims to see if one of two different medications works better to treat depression and mild memory problems in people living with HIV. Researchers will compare pramipexole, a drug that affects dopamine, to escitalopram, a common antidepressant. They will check how well t…

This study aims to understand how cat allergy shots (immunotherapy) change the body's immune response. Researchers will compare 16 cat-allergic adults: half who have been getting allergy shots for over a year and half who have never had this treatment. They will take small sample…

This study aims to identify blood markers that can predict whether children with suspected peanut allergy will react during a supervised feeding test. Researchers will enroll 500 children aged 1-17 years who may have peanut allergy. Participants will undergo a carefully monitored…

This study aims to understand how everyday exposures to chemicals in food, air, and personal care products affect our health. Healthy volunteers will spend two separate weeks in a hospital, living in either a 'pure' environment with filtered air and natural products or a 'common'…