Could a special liquid diet soothe IBD in rare immune disease?

NCT ID NCT03983837

Completed Symptom relief Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a liquid diet called Neocate Splash could change gut bacteria and ease stomach symptoms in people with chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD). Three participants followed the diet for up to 4 weeks, with hospital stays and follow-up visits. Researchers measured changes in gut bacteria and tracked side effects and symptom relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Neocate Splash (an amino acid-based liquid diet)
What this could lead to: If it works, this could point toward a dietary approach to manage IBD symptoms in people with CGD.
What could go wrong: This is a very small, early-phase study with only 3 participants, so results may not apply to others. The diet is restrictive and may be hard to tolerate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic granulomatous disease Crohn disease inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC GRANULOMATOUS DISEASE INFLAMMATORY BOWEL DISEASE

Contacts and locations

Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

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