Could a booster make your flu shot work better? new study investigates

NCT ID NCT03945825

Completed ⭐️ VACCINE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding special ingredients called adjuvants to two standard flu vaccines (Fluzone and Flublok) could make them work better. About 240 healthy adults aged 18 to 45 received either a regular flu shot or one with an adjuvant. Researchers checked for side effects and measured immune responses in blood samples over a year. The goal was to see if the adjuvanted vaccines were safe and produced stronger protection against the flu.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA INFLUENZA IMMUNISATION

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030-3411, United States
Cincinnati Children's Hospital Medical Center Vaccine Research Center

Cincinnati, Ohio, 45229-3039, United States
Duke Vaccine and Trials Unit

Durham, North Carolina, 27704, United States
Emory University School of Medicine

Atlanta, Georgia, 30322-1014, United States
Saint Louis University Center for Vaccine Development

St Louis, Missouri, 63104-1015, United States
University of Iowa - Vaccine Research and Education Unit

Iowa City, Iowa, 52242-2600, United States
University of Maryland Baltimore - School of Medicine - Medicine

Baltimore, Maryland, 21201-1509, United States
Vanderbilt University - Pediatric - Vanderbilt Vaccine Research Center

Nashville, Tennessee, 37232-2573, United States

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