Kidney function may change TB drug dosing

NCT ID NCT03896750

Completed Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study looked at how the tuberculosis drug pretomanid is processed in people with different levels of kidney function. Twelve participants received a single 200 mg dose, and researchers compared drug levels in those with kidney impairment to healthy matched controls. The goal was to see if kidney problems affect drug exposure, which could guide future dosing recommendations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pretomanid (PA-824)
What this could lead to: If successful, this study could help doctors determine the right dose of pretomanid for tuberculosis patients who also have kidney problems.
What could go wrong: This is a very early (Phase 1) study with only 12 participants, so results may not apply to everyone. It only looks at how the drug moves through the body, not whether it effectively treats TB.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

impaired renal function disease kidney failure tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL IMPAIRMENT TUBERCULOSIS

Contacts and locations

Locations

Advanced Pharma - Miami

Miami, Florida, 33147, United States
Alliance for Multispecialty Research, LLC - Knoxville

Knoxville, Tennessee, 37920, United States
Saint Louis University Center for Vaccine Development

St Louis, Missouri, 63104-1015, United States

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