Kidney function may change TB drug dosing
NCT ID NCT03896750
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how the tuberculosis drug pretomanid is processed in people with different levels of kidney function. Twelve participants received a single 200 mg dose, and researchers compared drug levels in those with kidney impairment to healthy matched controls. The goal was to see if kidney problems affect drug exposure, which could guide future dosing recommendations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pretomanid (PA-824)
What this could lead to
If successful, this study could help doctors determine the right dose of pretomanid for tuberculosis patients who also have kidney problems.
What could go wrong
This is a very early (Phase 1) study with only 12 participants, so results may not apply to everyone. It only looks at how the drug moves through the body, not whether it effectively treats TB.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advanced Pharma - Miami
Miami, Florida, 33147, United States
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Alliance for Multispecialty Research, LLC - Knoxville
Knoxville, Tennessee, 37920, United States
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Saint Louis University Center for Vaccine Development
St Louis, Missouri, 63104-1015, United States