New variant-targeted COVID boosters show promise in large trial
NCT ID NCT05289037
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tested updated mRNA vaccines designed to target specific COVID-19 variants, including Omicron. Over 1,200 adults who were already vaccinated received one or two doses of these variant vaccines. The goal was to see if these updated shots could boost the immune system's ability to recognize and fight new and emerging variants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mRNA vaccines (original and variant-specific) with or without an adjuvant (AS03)
What this could lead to
If successful, this could help design booster shots that better protect against emerging COVID-19 variants.
What could go wrong
This is a Phase 2 trial, so results are still early. The variant-specific vaccines may not offer significantly better protection than existing boosters, and immune responses can vary.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine
Houston, Texas, 77030-3411, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115-6110, United States
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Duke Vaccine and Trials Unit
Durham, North Carolina, 27703, United States
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Emory University School of Medicine
Atlanta, Georgia, 30322-1013, United States
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George Washington University Medical Faculty Associates
Washington D.C., District of Columbia, 20037-3201, United States
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Howard University - Department of Medicine - Division of Infectious Disease
Washington D.C., District of Columbia, 20060, United States
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Kaiser Permanente Washington Health Research Institute
Seattle, Washington, 98101, United States
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Morehouse School of Medicine - Clinical Research Center
Atlanta, Georgia, 30310, United States
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NYU Grossman School, NYU Langone Vaccine Center, Long Island
Mineola, New York, 11501, United States
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NYU Langone Vaccine Center Research Clinic, Manhattan
New York, New York, 10016, United States
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Saint Louis University Center for Vaccine Development
St Louis, Missouri, 63104-1015, United States
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The Hope Clinic of Emory University
Decatur, Georgia, 30030-1705, United States
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The University of Washington - Virology Research Clinic
Seattle, Washington, 98104, United States
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Tulane University Clinical Translational Unit
New Orleans, Louisiana, 70112, United States
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University of Alabama at Birmingham School of Medicine - Alabama Vaccine Research Clinic
Birmingham, Alabama, 35294, United States
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University of California, San Diego (UCSD) - Antiviral Research Center (AVRC)
San Diego, California, 92103-8208, United States
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University of Illinois at Chicago College of Medicine - Division of Infectious Diseases
Chicago, Illinois, 60612, United States
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University of Iowa Hospitals & Clinics - Department of Internal Medicine
Iowa City, Iowa, 52242, United States
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University of Rochester Medical Center - Vaccine Research Unit
Rochester, New York, 14611-3201, United States
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University of Texas Medical Branch
League City, Texas, 77573, United States
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Washington University School of Medicine in St. Louis - Infectious Disease Clinical Research Unit
St Louis, Missouri, 63110, United States
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Zuckerberg San Francisco General Hospital, UCSF Positive Health Program
San Francisco, California, 94110, United States