New hope for COVID-19 patients on ventilators: drug combo trial completed

NCT ID NCT04843761

Completed Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested two drugs—remdesivir and aviptadil—in hospitalized COVID-19 patients with severe breathing failure. About 473 participants received either a study drug plus standard care or a placebo plus standard care. The goal was to see if these drugs could safely improve outcomes for the sickest patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Remdesivir and Aviptadil (vasoactive intestinal peptide)
What this could lead to: If successful, these drugs could provide effective treatments for severe COVID-19 respiratory failure, potentially reducing deaths and speeding recovery.
What could go wrong: This is a completed Phase 3 trial, but results may not show clear benefit over standard care. Side effects from the drugs or placebo effects could complicate findings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Coronavinae infectious disease Coronaviridae Infections COVID-19 Nidovirales infectious disease RNA Virus Infections severe acute respiratory syndrome viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID19

Contacts and locations

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Locations

Banner University Medical Center Tucson (Site 206-004), 1625 N. Campbell Avenue

Tucson, Arizona, 85719, United States
Baylor, Scott and White Health (Site 301-003), Baylor University Medical Center, 3500 Gaston Ave.

Dallas, Texas, 75246, United States
Baystate Medical Center (Site 201-001), Critical Care Research, 759 Chestnut Street

Springfield, Massachusetts, 01199, United States
Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly Boulevard

Los Angeles, California, 90048, United States
Cleveland Clinic Fairview Hospital (Site 207-005), 18101 Lorain Ave.

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation (Site 207-001), 9500 Euclid Ave.

Cleveland, Ohio, 44195, United States
Cleveland Clinic Hillcrest Hospital (Site 207-007), 6780 Mayfield Road

Mayfield Heights, Ohio, 44124, United States
Cleveland Clinic Marymount Campus (Site 207-006), 12300 McCracken Road

Garfield Heights, Ohio, 44125, United States
Columbia University Irving Medical Center (Site 301-027), 177 Fort Washington Ave.

New York, New York, 10032, United States
Denver Health Medical Center (Site 204-004), 780 Delaware Street, Pavilion B

Denver, Colorado, 80204, United States
Duke University Hospital (Site 301-006), 2301 Erwin Road

Durham, North Carolina, 27710, United States
Emory University (Site 301-008), Bldg. A, Suite 2236, 1365 Clifton Rd., NE.

Atlanta, Georgia, 30322, United States
Harborview Medical Center (Site 208-001), 325 9th Ave.

Seattle, Washington, 98104, United States
Houston Methodist Hospital (Site 301-028), 6565 Fannin Street

Houston, Texas, 77030, United States
Intermountain Medical Center (Site 211-001), 5121 South Cottonwood Street

Murray, Utah, 84107, United States
Massachusetts General Hospital (Site 202-002), 55 Fruit Street

Boston, Massachusetts, 02114, United States
MedStar Health Research Institute (Site 009-021), 110 Irving St., NW.

Washington D.C., District of Columbia, 20010, United States
Medical University of South Carolina (Site 210-002), 96 Jonathan Lucas St., CSB 214

Charleston, South Carolina, 29425, United States
Montefiore Medical Center - Moses Hospital (Site 206-001), 111 E. 210th Street

The Bronx, New York, 10467, United States
Montefiore Medical Center - Weiler campus (Site 206-003), 111 E. 210th Street

The Bronx, New York, 10467, United States
Mount Sinai Medical Center (Site 301-012), Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place

New York, New York, 10029, United States
Oregon Health & Science University (Site 208-003), 3181 SW Sam Jackson Park Rd.

Portland, Oregon, 97239-3098, United States
Ronald Reagan UCLA Medical Center (Site 203-002), 757 Westwood Plaza

Los Angeles, California, 90095, United States
Stanford University Hospital & Clinics (Site 203-003), 300 Pasteur Dr.

Stanford, California, 94305, United States
Swedish Medical Center (Site 208-005), 747 Broadway

Seattle, Washington, 98122, United States
Texas Heart Institute (Site 301-017), 6770 Bertner, MC4-266

Houston, Texas, 77030, United States
The Ohio State University Wexner Medical Center (Site 207-004), 410 W. 10th Avenue

Columbus, Ohio, 43210, United States
UCSF Fresno (Site 203-005), 155 N. Fresno Street

Fresno, California, 93701, United States
UCSF Medical Center (Site 203-001), Moffit-Long Hospital, 505 Parnassus Ave.

San Francisco, California, 94143, United States
UCSF Medical Center at Mount Zion (Site 203-007), 1600 Divisadero St.

San Francisco, California, 94115, United States
UVA School of Medicine (Site 210-003), University of Virginia Health System, University Hospital, 1215 Lee St.

Charlottesville, Virginia, 22908, United States
University of Cincinnati Medical Center (Site 207-003), 234 Goodman Street, ML 0740

Cincinnati, Ohio, 45219, United States
University of Colorado Hospital (Site 204-001), 12605 E. 16th Avenue

Aurora, Colorado, 80045, United States
University of Texas Health Science Center (Site 203-006), 7000 Fannin St.

Houston, Texas, 77030, United States
University of Utah Hospital (Site 211-002), 50 North Medical Drive

Salt Lake City, Utah, 84132, United States
VA Loma Linda Healthcare System (Site 074-017), 11201 Benton Street

Loma Linda, California, 92357, United States
Vanderbilt University Medical Center (Site 212-001), 1211 Medical Center Drive

Nashville, Tennessee, 37232, United States
Wake Forest Baptist Health (Site 210-001), Medical Center Blvd

Winston-Salem, North Carolina, 27157, United States
Washington DC VA Medical Center (Site 009-004), 50 Irving Street, NW.

Washington D.C., District of Columbia, 20422, United States
West Virginia University Medicine (Site 301-023), One Medical Center Drive

Morgantown, West Virginia, 26506, United States

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