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Scientists probe genetic roots of Cold-Triggered hives

NCT ID NCT00887939

Completed Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why some people develop hives from physical triggers like cold, pressure, or sunlight. Researchers will test participants' skin reactions and collect blood and genetic samples to understand the role of immune cells and genes. The goal is to uncover the underlying causes of these conditions, which could lead to safer and more effective treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this study could reveal why some people get hives from physical triggers like cold or pressure, pointing toward better treatments.

What could go wrong

This is an observational study, not a treatment trial. It may not lead directly to new therapies, and results may not apply to all types of hives.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

autoinflammatory syndrome cryopyrin-associated periodic syndrome familial cold autoinflammatory syndrome familial dermatographia Hypersensitivity, Immediate IgE responsiveness, atopic physical urticaria urticaria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOINFLAMMATORY SYNDROMES FAMILIAL COLD AUTOINFLAMMATORY SYNDROME HYPERSENSITIVITY, IMMEDIATE PHYSICAL URTICARIA

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States