New yellow fever vaccine shows promise in early human trial
NCT ID NCT02743455
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage study tested a new yellow fever vaccine (MVA-BN-YF) in 92 healthy adults aged 18-45. Some volunteers received the vaccine alone, some with an adjuvant (ISA 720) to boost the immune response, and others received a placebo or a different vaccine. The main goal was to check safety and how well the body's immune system responds. Since this is a Phase I trial, it is too early to know if the vaccine will prevent yellow fever.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- MVA-BN Yellow Fever Vaccine with or without Montanide ISA 720 adjuvant
- What this could lead to
- If successful, this could lead to a new, safer yellow fever vaccine that may be easier to produce and distribute.
- What could go wrong
- This is an early Phase I trial with only 92 people, so it is too soon to know if the vaccine works. Side effects are possible, and the results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Saint Louis University Center for Vaccine Development
St Louis, Missouri, 63104-1015, United States
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University of Iowa - Vaccine Research and Education Unit
Iowa City, Iowa, 52242-2600, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New vaccines for yellow fever and rabies enter first human tests
- 10,000 people tested: Cambodia's massive disease hunt begins
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- New yellow fever vaccine shows promise in early safety trial
- New yellow fever vaccine shows promise in japanese adults