Could a shot help people with multiple food allergies eat peanuts safely?

NCT ID NCT03881696

Completed Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether omalizumab (Xolair), an allergy drug, helps people with peanut and at least two other food allergies eat those foods without severe reactions. Over 470 participants aged 1 to 55 received omalizumab or a placebo, and some also got oral immunotherapy. The goal was to see if they could tolerate a dose of peanut protein without symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: omalizumab (Xolair) and multi-allergen oral immunotherapy
What this could lead to: If successful, this could provide a new treatment option to help people with multiple food allergies tolerate small amounts of allergenic foods without severe reactions.
What could go wrong: This is a completed phase 3 trial, but results may not apply to all food allergies or ages. Omalizumab is not a cure and requires ongoing injections; risks include allergic reactions and side effects from the drug.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

food allergy Peanut Hypersensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTI-FOOD ALLERGY PEANUT ALLERGY

Contacts and locations

Locations

Arkansas Children's Hospital Research Institute: Department of Pediatrics, Allergy & Immunology

Little Rock, Arkansas, 72202, United States
Children's Hospital of Philadelphia: Division of Allergy and Immunology

Philadelphia, Pennsylvania, 19104, United States
Emory University School of Medicine: Children's Healthcare of Atlanta Pediatrics

Atlanta, Georgia, 30307, United States
Icahn School of Medicine at Mount Sinai: Department of Pediatrics Allergy & Immunology

New York, New York, 10029, United States
Johns Hopkins Children's Center: Department of Allergy & Immunology

Baltimore, Maryland, 21287, United States
Massachusetts General Hospital, Department of Medicine: Allergy & Clinical Immunology Unit

Boston, Massachusetts, 02114, United States
National Jewish Health: Division of Pediatric Allergy and Clinical Immunology

Denver, Colorado, 80206, United States
North Carolina Children's Hospital: Department of Pediatrics, Division of Allergy, Immunology and Rheumatology

Chapel Hill, North Carolina, 27599-7000, United States
Stanford School of Medicine: Sean N. Parker Center for Allergy & Asthma Research

Stanford, California, 94305, United States
University of Texas Southwestern Medical Center: Division of Allergy and Immunology

Dallas, Texas, 75390, United States

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