HIV prevention breakthrough: shot beats daily pill in large trial
NCT ID NCT02720094
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 23 times
Summary
This large study tested whether a long-acting injectable drug (cabotegravir) could prevent HIV infection better than daily oral pills in men and transgender women who have sex with men and are at high risk. Over 4,500 participants received either the injection every 8 weeks or a daily pill. The main goal was to see how many new HIV infections occurred and to check for side effects. Results showed the injection was highly effective and safe for preventing HIV.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ACSA CRS
Iquitos, Maynas, 1, Peru
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Adolescent & Young Adult Research at The CORE Center (AYAR at CORE)
Chicago, Illinois, 60612, United States
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Alabama CRS
Birmingham, Alabama, 35294, United States
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Barranco CRS
Lima, 15063, Peru
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Bridge HIV CRS
San Francisco, California, 94143, United States
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Bronx Prevention Research Center CRS
The Bronx, New York, 10451, United States
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CITBM - UNIDEC, Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales CRS
Bellavista, Provincia Constitucional del Callao, 15081, Peru
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CMU HIV Prevention CRS
Chiang Mai, 50202, Thailand
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Centro de Pesquisas Clínicas IC-HCFMUSP CRS
São Paulo, 05403-010, Brazil
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Centro de Referencia e Treinamento DST/AIDS CRS
São Paulo, São Paulo, 04121-000, Brazil
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Chapel Hill CRS
Chapel Hill, North Carolina, 27599, United States
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Children's Hospital Colorado CRS
Aurora, Colorado, 80045, United States
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Cincinnati Clinical Research Site
Cincinnati, Ohio, 45219, United States
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East Bay AIDS Center (EBAC) CRS
Oakland, California, 94609, United States
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Fenway Health (FH) CRS
Boston, Massachusetts, 02215-4302, United States
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Fundacion Huesped CRS
Buenos Aires, C1202ABB, Argentina
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George Washington Univ. CRS
Washington D.C., District of Columbia, 20037-1894, United States
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Greensboro CRS
Greensboro, North Carolina, 27401, United States
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Groote Schuur HIV CRS
Cape Town, Western Cape, 7925, South Africa
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Harlem Prevention Center CRS
New York, New York, 10027, United States
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Hospital General de Agudos JM Ramos Mejía CRS
Ciudad de Buenos Aires, Buenos Aires, C1221ADC, Argentina
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Hospital Nossa Senhora da Conceicao CRS
Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
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Houston AIDS Research Team CRS
Houston, Texas, 77030, United States
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Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS
Rio de Janeiro, 21040-360, Brazil
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Johns Hopkins University CRS
Baltimore, Maryland, 21205, United States
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New Jersey Medical School Clinical Research Center CRS
Newark, New Jersey, 07103, United States
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New Orleans Adolescent Trials Unit CRS
New Orleans, Louisiana, 70112, United States
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New York Blood Center CRS
New York, New York, 10065, United States
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Ohio State University CRS
Columbus, Ohio, 43210, United States
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Penn Prevention CRS
Philadelphia, Pennsylvania, 19104, United States
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San Miguel CRS
Lima, 32 - 15088, Peru
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Silom Community Clinic CRS
Bangkok, Changwat Nonthaburi, 11000, Thailand
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St. Jude Children's Research Hospital CRS
Memphis, Tennessee, 38105-3678, United States
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Thai Red Cross AIDS Research Centre (TRC-ARC) CRS
Pathum Wan, Bangkok, 10330, Thailand
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The Hope Clinic of the Emory Vaccine Center CRS
Decatur, Georgia, 30030, United States
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The Ponce de Leon Center CRS
Atlanta, Georgia, 30308-2012, United States
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UCLA CARE Center CRS
Los Angeles, California, 90035, United States
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UCLA Vine Street Clinic CRS
Los Angeles, California, 90024, United States
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UIC Project WISH CRS
Chicago, Illinois, 60612, United States
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Via Libre CRS
Lima, 15001, Peru
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Washington University Therapeutics (WT) CRS
St Louis, Missouri, 63110-1010, United States
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Weill Cornell Chelsea CRS
New York, New York, 10010, United States
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Yen Hoa Health Clinic CRS
Hanoi, 100000, Vietnam
Conditions
Explore the condition pages connected to this study.