New combo therapy aims to tame kidney disease
NCT ID NCT03949855
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether adding belimumab to standard rituximab treatment helps more people with primary membranous nephropathy achieve remission. The study enrolls 58 adults with confirmed disease. Belimumab targets new immune cells, while rituximab depletes existing ones, aiming to reduce kidney damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
belimumab (Benlysta) and rituximab
What this could lead to
If successful, this combination could offer a more effective treatment for membranous nephropathy, potentially leading to longer-lasting remission with fewer side effects.
What could go wrong
This is a small Phase 2 trial, so results may not apply to all patients. Neither drug is FDA-approved for this condition, and combining them may increase infection risk or other side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia University Medical Center: Division of Nephrology
RECRUITINGNew York, New York, 10032, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johns Hopkins
RECRUITINGBaltimore, Maryland, 21287, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic Jacksonville: Department of Nephrology and Hypertension
RECRUITINGJacksonville, Florida, 32224, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Ohio State University Wexner Medical Center: Division of Nephrology
RECRUITINGColumbus, Ohio, 43210, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Providence Medical Research Center, Providence Health Care: Nephrology
RECRUITINGSpokane, Washington, 99204, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford University School of Medicine: Division of Nephrology
RECRUITINGStanford, California, 94305, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
Contact
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The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center:Division of Nephrology and Hypertension
RECRUITINGTorrance, California, 90502, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Alabama at Birmingham School of Medicine: Division of Nephrology
RECRUITINGBirmingham, Alabama, 35294, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Arkansas
RECRUITINGLittle Rock, Arkansas, 72205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco
RECRUITINGSan Francisco, California, 94146, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Miami Miller School of Medicine, Div of Nephrology
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota Health Clinical Research Unit
RECRUITINGMinneapolis, Minnesota, 55455, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Nebraska
RECRUITINGOmaha, Nebraska, 68198, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of North Carolina School of Medicine: Division of Nephrology and Hypertension, Kidney Center
RECRUITINGChapel Hill, North Carolina, 27599-, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Pennsylvania: Department of Medicine: Renal-Electrolyte and Hypertension Division
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact