New hope for lupus nephritis: experimental drug VIB4920 enters Mid-Stage trial
NCT ID NCT05201469
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called VIB4920 in people with active lupus nephritis, a serious kidney complication of lupus. About 74 adults will receive either VIB4920 or a placebo, along with standard medications, to see if the drug helps improve kidney function. The goal is to find a better way to control the disease and reduce kidney damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
VIB4920 (an experimental drug given by IV infusion)
What this could lead to
If it works, this could point toward a new treatment option for lupus nephritis, potentially helping more people achieve kidney remission.
What could go wrong
This is an early phase 2 trial with only 74 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Columbia University Medical Center: Department of Medicine, Division of Rheumatology
RECRUITINGNew York, New York, 10032, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Emory University School of Medicine: Division of Rheumatology
RECRUITINGAtlanta, Georgia, 30307, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Feinstein Institute for Medical Research: Center for Autoimmune and Musculoskeletal Diseases
RECRUITINGManhasset, New York, 11030, United States
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital for Special Surgery, New York: Division of Rheumatology
NOT_YET_RECRUITINGNew York, New York, 10021, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Penn State Health Milton S. Hershey Medical Center: Division of Rheumatology
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact Phone: •••-•••-••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Temple University, Lewis Katz School of Medicine, Department of Medicine: Nephrology
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UCLA Medical Center: Division of Rheumatology
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of California San Diego School of Medicine: Division of Rheumatology, Allergy and Immunology
RECRUITINGLa Jolla, California, 92093, United States
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco School of Medicine: Lupus Clinic and Rheumatology Clinical Research Center
RECRUITINGSan Francisco, California, 94143, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Chicago, Department of Medicine: Rheumatology
RECRUITINGChicago, Illinois, 60637, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Colorado School of Medicine: Division of Rheumatology
RECRUITINGAurora, Colorado, 80045, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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University of Miami Miller School of Medicine: Nephrology & Hypertension Division
RECRUITINGMiami, Florida, 33136, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Email: •••••@•••••
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University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University School of Medicine in St. Louis: Division of Nephrology
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Yale University School of Medicine: Section of Rheumatology
RECRUITINGNew Haven, Connecticut, 06519, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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of California, Irvine School of Medicine Division of Rheumatology
RECRUITINGOrange, California, 92868, United States
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••