20,000 volunteers needed to decode immune disease genetics

NCT ID NCT03206099

Recruiting now Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 13, 2026 · Updated 15 times

Summary

This study will analyze DNA from up to 20,000 people, including those with immune disorders and their relatives, to find genetic variants linked to conditions like atopy, autoimmunity, and primary immunodeficiency. Researchers will also study how best to return genetic results to participants. The goal is to better understand the genetics of these diseases and improve clinical genetic services.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help identify new genetic causes of immune disorders and improve how genetic results are shared with patients.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and some genetic findings may be uncertain or not actionable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic IgE-mediated allergic disorder autoimmune disease autoinflammatory syndrome inborn error of immunity Primary Immunodeficiency Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPY AUTOIMMUNITY AUTOINFLAMMATION PRIMARY IMMUNODEFICIENCY

Contacts and locations

Locations

Children's National Health System
RECRUITING

Washington D.C., District of Columbia, 20010, United States
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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