Massive study seeks genetic clues to immune disorders

NCT ID NCT03610802

Recruiting now Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This study aims to collect blood, saliva, and other samples from up to 3,000 people with primary immunodeficiency (PID) or their relatives. Researchers will analyze the samples to find genetic causes of PID. The goal is to better understand these inherited immune disorders, which can lead to better diagnosis and future treatments. No experimental treatments are given.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify new genetic causes of primary immunodeficiency, potentially guiding future treatments.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and genetic findings may not lead to immediate therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

inborn error of immunity Primary Immunodeficiency Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY IMMUNODEFICIENCY

Contacts and locations

Locations

Marmara University Hospital, Istanbul Jeffrey Modell Diagnostic and Research Cen
RECRUITING

Istanbul, Turkey (Türkiye)
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
Pavia Hospital (PH)
RECRUITING

Pavia, 27100, Italy

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